14 results found
    1. Biochemistry and Chemical Biology

    RNA World: Visualizing primer extension without enzymes

    John C Chaput
    X-ray crystallography has been used to observe the synthesis of RNA in the absence of enzymes with atomic resolution.
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    1. Ecology
    2. Human Biology and Medicine

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium

    David R Hill et al.
    Contact with bacteria and subsequent hypoxia promotes functional maturation of the immature gastrointestinal tract.
    1. Biochemistry and Chemical Biology

    Random-sequence genetic oligomer pools display an innate potential for ligation and recombination

    Hannes Mutschler et al.
    Random sequence RNA pools display an innate capacity for ligation and recombination, enabling them to “bootstrap” themselves towards higher compositional, informational and structural complexity.
    1. Biochemistry and Chemical Biology

    Ribozyme-catalysed RNA synthesis using triplet building blocks

    James Attwater et al.
    Adopting RNA trinucleotides as substrates, ribozymes can catalyse the copying of structured RNA sequences, allowing self-synthesis by part of a newly evolved symbiotic ribozyme pair.
    1. Biochemistry and Chemical Biology

    Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides

    Noam Prywes et al.
    Nonenzymatic polymerization can copy templates containing all four RNA monomers, a prerequisite for the transition to the RNA world.
    1. Physics of Living Systems

    High-molecular-weight polymers from dietary fiber drive aggregation of particulates in the murine small intestine

    Asher Preska Steinberg et al.
    Polymers from dietary fiber can control the aggregation of particulates in the murine small intestine in a manner qualitatively consistent with depletion interactions.
    1. Microbiology and Infectious Disease

    Gut bacteria are rarely shared by co-hospitalized premature infants, regardless of necrotizing enterocolitis development

    Tali Raveh-Sadka et al.
    Rapid yet comprehensive, genome-resolved analysis of fecal samples from premature infants reveals little overlap in strain composition of gut microbial communities, despite co-hospitalization, and suggests the existence of barriers to strain dispersal.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of chiral proofreading during translation of the genetic code

    Sadeem Ahmad et al.
    Structural biology has elucidated the mechanism of a configuration-specific enzyme that decouples D-amino acids from the translational machinery and, therefore, is involved in the enforcement of homochirality during protein synthesis.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A vocabulary of ancient peptides at the origin of folded proteins

    Vikram Alva et al.
    A comparative study of modern proteins identifies 40 fragments that may represent the observable remnants of a primordial RNA-peptide world.

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