46 results found
    1. Computational and Systems Biology

    Metage2Metabo, microbiota-scale metabolic complementarity for the identification of key species

    Arnaud Belcour et al.
    Computational models and software connect metagenomics to metabolic network reconstruction, assess metabolic complementarity between species, and identify critical species associated to functions of interest.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription

    Rozenn Riou et al.
    A chromatin remodeling factor cooperates with Wnt signaling pathway to transcribe erythropoietin in the adult liver, inducing its secretion and a dramatic erythropoiesis in the spleen.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Vilya, a component of the recombination nodule, is required for meiotic double-strand break formation in Drosophila

    Cathleen M Lake et al.
    The Zip3-like protein Vilya links the initiation of meiotic recombination with crossover formation.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium

    David R Hill et al.
    Contact with bacteria and subsequent hypoxia promotes functional maturation of the immature gastrointestinal tract.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

    Min Jung et al.
    A statistical method for summarizing single-cell gene expression data identifies normal and disease-specific transcriptional programs from an atlas of 57,600 cells.
    1. Genetics and Genomics

    Genome-wide mapping in a house mouse hybrid zone reveals hybrid sterility loci and Dobzhansky-Muller interactions

    Leslie M Turner, Bettina Harr
    The genomic regions that cause male hybrids between house mouse subspecies to have low fertility have been identified.
    1. Evolutionary Biology

    A Bayesian approach to dynamic homology of morphological characters and the ancestral phenotype of jawed vertebrates

    Benedict King, Martin Rücklin
    The ancestor of all known jawed vertebrates possessed a maxilla and premaxilla and was similar in morphology to the 'maxillate placoderms' from China.
    1. Microbiology and Infectious Disease

    Resilience of small intestinal beneficial bacteria to the toxicity of soybean oil fatty acids

    Sara C Di Rienzi et al.
    Comparisons between lactobacilli bacteria in the small intestine and those evolved in the lab reveal several modes of resistance to toxic fatty acids.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Extensive transmission of microbes along the gastrointestinal tract

    Thomas SB Schmidt et al.
    Microbial populations are continuous along the gastrointestinal tract, with increased transmission in colorectal cancer and rheumatoid arthritis patients.
    1. Developmental Biology
    2. Genetics and Genomics

    Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris

    Brent A Wilkerson et al.
    The elucidation of the cellular composition of the crista and the genes expressed in each cell type is a critical step toward understanding inner ear development, function, and vestibulopathies.

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