Minh Q Nguyen, Lars J von Buchholtz ... Steve Davidson
Single-nucleus transcriptomics exposes unique features of human somatosensory neurons and clues that may help resolve repeated problems in translating new experimental approaches for treating pain.
Pierre Khoueiry, Charles Girardot ... Eileen EM Furlong
Interspecies comparison of transcription factor occupancy during embryogenesis reveals potential co-operative relationships between factors and uncovers the inherent plasticity of developmental enhancers to overcome divergence in transcription factor occupancy.
Synthetic biology experiments show that MYC is a general transcription amplifier acting at two or more sites in the transcription-cycle and that MYC-turnover contributes to its activity.
Maria Pernemalm, AnnSofi Sandberg ... Janne Lehtiö
Comprehensive mass spectrometry analysis of human plasma proteome reveals tissue leakage proteins, describes variability between individual plasma proteomes and demonstrates protein transfer across the placenta during pregnancy.
Xinle Zou, Sri Karthika Shanmugam ... Henry M Colecraft
Targeted recruitment of protein kinase A subunits enables distinctive regulation of the functional expression of a potassium channel depending on whether the enzyme is targeted to a pore-forming or auxiliary subunit.
A high-throughput analysis of several self-cleaving ribozymes reveals the effect of every possible mutation, and every possible pair of mutations, and how patterns in the relative activity data can be mapped to canonical and non-canonical structural elements.
How large-scale single mosquito metatranscriptomics can define the mosquito’s complex microbiota and its blood meal sources, and contribute critical epidemiological information needed to control vector borne disease transmission, is shown.
Sumanprava Giri, Vasudha Aggarwal ... Supriya G Prasanth
Origin recognition complex-associated (ORCA) is crucial for the stability of the Histone H3 lysine 9 methyltransferase megacomplex, which is essential for heterochromatin organization.
The pseudokinase Tribbles1 is expressed in human monocytes after mycobacterial challenge and can be manipulated to be host protective against mycobacterial infection, due to control of innate immune cell function, in a zebrafish tuberculosis model.
