2,963 results found
    1. Biochemistry and Chemical Biology

    The GTPase Nog1 co-ordinates the assembly, maturation and quality control of distant ribosomal functional centers

    Purnima Klingauf-Nerurkar et al.
    The GTPase Nog1 orchestrates stalk assembly, peptidyl transferase centre maturation and polypeptide exit tunnel quality control.
    1. Developmental Biology
    2. Neuroscience

    A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture

    Alfredo Llorca et al.
    The specification of a very small number of progenitor cells with competence to adapt their neurogenic output to different probabilistic rules underlies the generation of distinct cortical cytoarchitectures.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations

    Birong Shen et al.
    Accumulation of mutations in some cancers is correlated with an aberration of DNA repair and access of a DNA deaminase to normal genomic DNA.
  1. Road

    Innovation Leaders 2020: Introducing the cohort

    We announce the participants and projects joining our new mentorship and open leadership training programme.
    1. Neuroscience

    Homeostatic regulation of perisynaptic matrix metalloproteinase 9 (MMP9) activity in the amblyopic visual cortex

    Sachiko Murase et al.
    Dark exposure lowers the MMP9 activation threshold, and subsequent light stimulation to an amblyopic eye is sufficient to induce proteolysis at thalamo-cortical synapses in deprived mouse visual cortex.
    1. Cell Biology
    2. Developmental Biology

    Telophase correction refines division orientation in stratified epithelia

    Kendall J Lough et al.
    Telophase reorientation corrects errors in spindle orientation that persist after imprecise initial spindle positioning during early mitosis, and contributes to balancing self-renewal with differentiation during epidermal development.
    1. Structural Biology and Molecular Biophysics

    Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement

    Avinash B Patel et al.
    The structure of the yeast RSC complex, a member of the SWI/SNF chromatin remodeling family, determined by cryo-electron microscopy, reveals a conserved structural core and the mode of nucleosome engagement.
    1. Physics of Living Systems

    Flower-like patterns in multi-species bacterial colonies

    Liyang Xiong et al.
    Mechanical interactions between bacterial species with different motility characteristics play an important role in spatial-temporal dynamics of multi-species bacterial colonies and can lead to formation of complex patterns.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification

    Matthew T Parker et al.
    Sequencing mRNA directly with nanopores can reveal the authentic combinations of multiple mRNA processing events in full-length mRNA molecules in addition to identifying base modifications.
    1. Cell Biology

    Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model

    Magdalena Kasendra et al.
    Combining Organs-on-Chips technology with adult intestinal organoids provides an improved model of human duodenum and a new platform for preclinical drug assessment.

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