3,852 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Mitochondria-specific photoactivation to monitor local sphingosine metabolism and function

    Suihan Feng et al.
    Caged, photoactivatible sphingosine localized to mitochondria permits demonstration of the importance of subcellular localization on lipid metabolism and signaling.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Impact of the scale-up of piped water on urogenital schistosomiasis infection in rural South Africa

    Frank Tanser et al.
    Scale-up of safe water supplies decreases a child's risk of urogenital schistosomiasis infection by eight-fold in a typical rural African population.
    1. Ecology

    Implications of being born late in the active season for growth, fattening, torpor use, winter survival and fecundity

    Britta Mahlert et al.
    Being born late in the active season is associated with a fast life history in a hibernating species, the garden dormouse (Eliomys quercinus).
    1. Biophysics and Structural Biology

    Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions

    Ashok Sekhar et al.
    NMR-based flux measurements show that both bacterial and human Hsp70 chaperones interact with helical, as well as sheet substrates predominantly through a conformational selection mechanism.
    1. Genes and Chromosomes

    Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres

    Juan Manuel Povedano et al.
    Telomerase gene therapy represents a novel effective treatment for pulmonary fibrosis associated with short telomeres by improving pulmonary function, decreasing inflammation and accelerating fiber disappearance in fibrotic lungs.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology and Stem Cells

    Crk proteins transduce FGF signaling to promote lens fiber cell elongation

    Tamica N Collins et al.
    Crk proteins are critical mediators of FGF signaling to control cell shape changes.
    1. Neuroscience

    The modulation of neural gain facilitates a transition between functional segregation and integration in the brain

    James M Shine et al.
    The flexible network architecture of the brain is sensitive to the modulation of neural gain, which may be mediated by ascending arousal nuclei, such as the noradrenergic locus coeruleus.
    1. Developmental Biology and Stem Cells

    Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate

    Silja Barbara Burkhard, Jeroen Bakkers
    A genome wide transcriptome dataset of the embryonic zebrafish heart with high spatial resolution was established and used to identify a novel mechanism regulating pacemaker function.
    1. Cell Biology
    2. Plant Biology

    Stromule extension along microtubules coordinated with actin-mediated anchoring guides perinuclear chloroplast movement during innate immunity

    Amutha Sampath Kumar et al.
    Stromules induced during plant innate immunity dynamically interact and use the cytoskeleton to form and to direct the movement of chloroplasts.
    1. Cell Biology

    TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells

    Katerina Leonova et al.
    Type I interferon signaling protects cells from the loss of epigenetic integrity, since it is activated in cells in response to accumulation of transcripts originating from normally silenced heterochromatin, caused by small-molecule-mediated nucleosome unfolding.

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