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    1. Neuroscience

    Response-based outcome predictions and confidence regulate feedback processing and learning

    Romy Frömer et al.
    Computational modeling, and empirical behavioral and EEG results show that learning relies not only on comparing current events to past experience, but integrates response-based outcome predictions and confidence.
    1. Neuroscience

    Dopamine neuron ensembles signal the content of sensory prediction errors

    Thomas A Stalnaker et al.
    Dopamine neurons function as an ensemble to signal a multidimensional feature prediction error.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Prediction of enzymatic pathways by integrative pathway mapping

    Sara Calhoun et al.
    A computational method identifies the functions of orphan enzymes by organizing them into metabolic pathways; the prediction of a new l-gulonate catabolic pathway is experimentally tested and confirmed.
    1. Neuroscience

    Midbrain dopamine neurons compute inferred and cached value prediction errors in a common framework

    Brian F Sadacca et al.
    Midbrain dopamine neurons in rats signal discrepancies between predicted and actual rewards, regardless of whether the rewards are predicted on the basis of experience or inference.
    1. Neuroscience

    Specific lexico-semantic predictions are associated with unique spatial and temporal patterns of neural activity

    Lin Wang et al.
    The prediction of specific words is associated with distinct spatial and temporal patterns of neural activity within the left inferior and medial temporal regions before the predicted word is presented.
    1. Cancer Biology
    2. Genetics and Genomics

    Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction

    Shixiang Wang et al.
    Tumor immunogenicity is quantified with a novel method, and the resulting tumor immunogenicity score is an effective tumor-inherent biomarker for prediction of response to immune checkpoint inhibitors.
    1. Evolutionary Biology

    Robust and accurate prediction of residue–residue interactions across protein interfaces using evolutionary information

    Sergey Ovchinnikov et al.
    Co-evolving residue pairs in the different components of a protein complex almost always make contact across the protein–protein interface, thus providing powerful restraints for the modeling of protein complexes.
    1. Neuroscience

    A prediction model of working memory across health and psychiatric disease using whole-brain functional connectivity

    Masahiro Yamashita et al.
    Human neuroimaging and machine learning reveals a generalizable relationship between brain connectivity and working memory ability across healthy populations and distinct psychiatric diagnoses.
    1. Neuroscience

    Rapid computations of spectrotemporal prediction error support perception of degraded speech

    Ediz Sohoglu, Matthew H Davis
    Analysis of speech acoustics and human brain activity reveals the neural computations by which listeners combine speech input with prior expectations.
    1. Neuroscience

    Prediction error and repetition suppression have distinct effects on neural representations of visual information

    Matthew F Tang et al.
    Multivariate analyses of human electrophysiological recordings revealed that the brain represents unexpected visual stimuli with greater fidelity than expected stimuli which arose independently of simple habituation arising from repetition.