2,547 results found
    1. Biochemistry and Chemical Biology

    Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics

    Syed M Moin, Sinisa Urban
    Intramembrane proteases identify target proteins in a different way from other proteases.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure

    Taesun Eom, Chaolin Zhang ... Robert B Darnell
    The HITS-CLIP sequencing method is used to demonstrate that cryptic exons can detect messenger RNA that contains nonsense mutations, and then cause this RNA to decay, which shows that these exons are involved in maintaining the electrical balance of neurons and, possibly, preventing epilepsy.
    1. Neuroscience

    Convergence of pontine and proprioceptive streams onto multimodal cerebellar granule cells

    Cheng-Chiu Huang, Ken Sugino ... Adam W Hantman
    Individual granule cells within the cerebellum-the region of the brain that coordinates movement and supports the learning of new motor skills-receive both sensory and motor input streams: an arrangement that may help the brain to use feedback to fine-tune movement.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract

    Joshua T Schiffer, David Swan ... Lawrence Corey
    A combination of detailed sampling and mathematical modeling suggests that the response of immune cells to reactivation of herpes simplex virus 2 is extremely rapid and effective within microscopic areas of genital skin.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage

    Ashley L St John, Abhay PS Rathore ... Soman N Abraham
    Proteins produced by mast cells modulate the permeability of blood vessels, and may determine whether patients infected with dengue virus develop life-threatening complications.
    1. Neuroscience

    Decoding the neural mechanisms of human tool use

    Jason P Gallivan, D Adam McLean ... Jody C Culham
    Imaging experiments reveal that some brain regions do not distinguish between actions performed using tools and those performed using the hands, while others represent these two types of action separately.
    1. Genetics and Genomics

    Integrative genomic analysis of the human immune response to influenza vaccination

    Luis M Franco, Kristine L Bucasas ... Chad A Shaw
    By comparing gene expression in people before and after they received the influenza vaccine, researchers were able to identify genes that contribute to differences in individual responses to vaccination.
    1. Developmental Biology

    Cellular resolution models for even skipped regulation in the entire Drosophila embryo

    Garth R Ilsley, Jasmin Fisher ... Nicholas M Luscombe
    A statistical model is able to predict patterns of gene expression output in Drosophila embryos using only the cellular concentrations of transcription factors as input.
    1. Plant Biology

    Phenotypic landscape inference reveals multiple evolutionary paths to C4 photosynthesis

    Ben P Williams, Iain G Johnston ... Julian M Hibberd
    Computational modelling indicates that C4 photosynthesis in distantly related plant species arose through a number of independent evolutionary paths.

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