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    1. Neuroscience

    Distinct roles of visual, parietal, and frontal motor cortices in memory-guided sensorimotor decisions

    Michael J Goard, Gerald N Pho ... Mriganka Sur
    Visual, parietal, and frontal motor cortices play distinct and necessary roles in mapping sensory features to future motor action.
    1. Chromosomes and Gene Expression

    A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans

    Kevin I Manage, Alicia K Rogers ... Carolyn Marie Phillips
    SIMR-1 acts downstream of the piRNA pathway to promote siRNA amplification by the Mutator complex and localizes to perinuclear foci distinct from Mutator foci, P granules and Z granules.
    1. Neuroscience

    Dynamic encoding of social threat and spatial context in the hypothalamus

    Piotr Krzywkowski, Beatrice Penna, Cornelius T Gross
    Threat and context-responsive neurons in the ventromedial hypothalamus are reshaped by experience to drive social avoidance.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Fibroblast growth factors (FGFs) prime the limb specific Shh enhancer for chromatin changes that balance histone acetylation mediated by E26 transformation-specific (ETS) factors

    Silvia Peluso, Adam Douglas ... Robert E Hill
    FGF signalling is responsible for priming the developmental enhancer ZRS across the distal limb mesenchyme during development, allowing ETS factors to modulate its activity through balancing histone acetylation.
    1. Neuroscience

    An open-source platform for head-fixed operant and consummatory behavior

    Adam Gordon-Fennell, Joumana M Barbakh ... Garret D Stuber
    A customizable open-source hardware and software platform for conducting diverse behavioral experiments in head-fixed mice.
    1. Neuroscience

    The wiring diagram of a glomerular olfactory system

    Matthew E Berck, Avinash Khandelwal ... Albert Cardona
    The complete neural circuit map of a tractable olfactory system will support studies towards bridging the gap between circuits and behavior.
    1. Neuroscience

    A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

    Brad K Hulse, Hannah Haberkern ... Vivek Jayaraman
    An analysis of the first complete synaptic resolution connectome of Drosophila's navigation circuit uncovers neural network motifs supporting broadly relevant sensorimotor computations.
    1. Neuroscience

    The integrated brain network that controls respiration

    Friedrich Krohn, Manuele Novello ... Laurens WJ Bosman
    The primary rhythm generators controlling respiration are integrated in a much larger network of brain regions, including areas not typically considered to be respiratory control centers, and that allow respiration to be adapted to all forms of ongoing behavior.
    1. Cancer Biology
    2. Genetics and Genomics

    Functional CDKN2A assay identifies frequent deleterious alleles misclassified as variants of uncertain significance

    Hirokazu Kimura, Raymond M Paranal ... Nicholas J Roberts
    Over 40% of CDKN2A variants of uncertain significance identified in patients with pancreatic cancer are functionally deleterious and can be reclassified as likely pathogenic with implications for care of patients and their relatives.
    1. Cell Biology

    The number of cytokinesis nodes in mitotic fission yeast scales with cell size

    Wasim A Sayyad, Thomas D Pollard
    Fission yeasts cells have about 190 cytokinesis nodes in a broad band at the equator which scales with cell size and most but not all nodes condense into the contractile ring.