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    1. Physics of Living Systems

    Decoding phase separation of prion-like domains through data-driven scaling laws

    M Julia Maristany, Anne Aguirre Gonzalez ... Jerelle A Joseph
    Phase diagrams for 140 variants of prion-like low-complexity domains are computed to establish scaling laws that quantify the impact of amino acid mutations on the thermodynamic stability of condensates.
    1. Computational and Systems Biology

    A transfer-learning approach to predict antigen immunogenicity and T-cell receptor specificity

    Barbara Bravi, Andrea Di Gioacchino ... Rémi Monasson
    An interpretable machine learning approach can recapitulate the molecular features associated to immune protein-protein binding and leverage them for the prediction of immune response specificity.
    1. Cell Biology
    2. Physics of Living Systems

    Persistent cell migration emerges from a coupling between protrusion dynamics and polarized trafficking

    Kotryna Vaidžiulytė, Anne-Sophie Macé ... Mathieu Coppey
    Quantitative proof that persistent cell migration in the timescale of hours relies on a feedback between polarized trafficking and protrusive activity stabilizing cell front.
    1. Cancer Biology
    2. Computational and Systems Biology

    Unveiling the signaling network of FLT3-ITD AML improves drug sensitivity prediction

    Sara Latini, Veronica Venafra ... Francesca Sacco
    Acute myeloid leukemia-specific predictive logic models reveal new therapeutic targets involved in cancer resistance mechanisms paving the way for personalized precision medicine.
    1. Neuroscience

    Using recurrent neural network to estimate irreducible stochasticity in human choice behavior

    Yoav Ger, Moni Shahar, Nitzan Shahar
    Applying deep learning tools to pinpoint predictive gaps in behavioral cognitive modeling.
    1. Physics of Living Systems

    Learning developmental mode dynamics from single-cell trajectories

    Nicolas Romeo, Alasdair Hastewell ... Jörn Dunkel
    A computational framework enables the inference of hydrodynamic continuum models for collective cell migration from live-cell imaging data recorded in zebrafish embryos.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    A simple regulatory architecture allows learning the statistical structure of a changing environment

    Stefan Landmann, Caroline M Holmes, Mikhail Tikhonov
    Minimal modifications of common regulatory circuits can allow bacteria to learn from the past to better predict the future, on a physiological, rather than evolutionary, timescale.
    1. Neuroscience

    NeuroQuery, comprehensive meta-analysis of human brain mapping

    Jérôme Dockès, Russell A Poldrack ... Gaël Varoquaux
    Full-text analysis of the human brain-imaging literature can predict the spatial distribution of observations in the brain given the description of a subject of study.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry

    Wei Q Deng, Nathan Cawte ... Sonia S Anand
    Epigenetic signature of maternal smoking contributes to smaller body size and lower birth weight in newborns of European and South Asian ancestry.
    1. Neuroscience

    Combining magnetoencephalography with magnetic resonance imaging enhances learning of surrogate-biomarkers

    Denis A Engemann, Oleh Kozynets ... Alexandre Gramfort
    Predicting age jointly from multimodal brain images and electrophysiology with machine learning enhances detecting health issues and facets of cognitive decline.