Dopamine neurons function as an ensemble to signal a multidimensional feature prediction error.

A computational method identifies the functions of orphan enzymes by organizing them into metabolic pathways; the prediction of a new l-gulonate catabolic pathway is experimentally tested and confirmed.

Midbrain dopamine neurons in rats signal discrepancies between predicted and actual rewards, regardless of whether the rewards are predicted on the basis of experience or inference.

The anticipation of rewards turns out to have its own hedonic value, on top of that of the reward itself; a wide range of behavioral and neurophysiological data suggest that this anticipation is boosted by prediction errors.

A new type of implicit effects on one's actions induced by prediction errors during action observation is discovered.

Activity in the midbrain responds to unexpected changes in outcome identity (i.e. sensory prediction error) but does not scale with perceptual distance between expected and receipt reward.

Prediction of future input explains diverse neural tuning properties in sensory cortex.

Large-scale replication study with brain potentials challenges the view that people routinely predict the phonological form of a predictable word during language comprehension.

Site-specific DNA methylation analysis at three CG dinucleotides by pyrosequencing provides a reliable measure for epigenetic aging of mice.

The brain continuously updates the learned temporal relationship between motor commands and their associated somatosensory feedback, which determines the perceived intensity and ticklishness of self-touch.