1,289 results found
    1. Neuroscience

    Rapid learning of predictive maps with STDP and theta phase precession

    Tom M George, William de Cothi ... Caswell Barry
    A close approximation to the successor representation is learnt by a simple spike-time-dependent learning rule between cells undergoing theta phase precession.
    1. Epidemiology and Global Health

    Point of View: COVID-19 as a catalyst for reimagining cervical cancer prevention

    Rebecca Luckett, Sarah Feldman ... Suzanne Garland
    The Policy Committee of the International Papillomavirus Society describes how lessons learnt from the COVID-19 pandemic could propel a new approach to the elimination of cervical cancer that is more likely to be successful.
    1. Epidemiology and Global Health

    Building resilient cervical cancer prevention through gender-neutral HPV vaccination

    Irene Man, Damien Georges ... Iacopo Baussano
    Shifting from girls-only to gender-neutral HPV vaccination strategy improves the resilience of cervical cancer prevention and enhances progress towards cervical cancer elimination.
    1. Epidemiology and Global Health

    An umbrella review of systematic reviews on the impact of the COVID-19 pandemic on cancer prevention and management, and patient needs

    Taulant Muka, Joshua JX Li ... John PA Ioannidis
    A diverse and substantial impact of the COVID-19 pandemic on cancer care is observed, including delays in treatment, screening, and diagnosis, as well as on the psychosocial welling of patients with cancer.
    1. Chromosomes and Gene Expression

    The nucleosome DNA entry-exit site is important for transcription termination and prevention of pervasive transcription

    A Elizabeth Hildreth, Mitchell A Ellison ... Karen M Arndt
    Disruption of the nucleosome DNA entry-exit site causes readthrough transcription of terminators, decreased nucleosome occupancy, and pervasive noncoding transcription, demonstrating this nucleosomal region protects the genome against inappropriate transcription.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Deep-sequence phylogenetics to quantify patterns of HIV transmission in the context of a universal testing and treatment trial – BCPP/Ya Tsie trial

    Lerato E Magosi, Yinfeng Zhang ... Marc Lipsitch
    HIV transmissions into intervention communities from control communities in the Botswana/Ya Tsie trial were similar to the reverse at baseline, and 10 times more common post-baseline, concordant with a predicted benefit of a universal test-and-treat HIV prevention intervention.
    1. Neuroscience

    Firing rate adaptation affords place cell theta sweeps, phase precession, and procession

    Tianhao Chu, Zilong Ji ... Si Wu
    Adaptation within a continuous attractor neural network explains theta phase precession and procession, providing insight into the neural mechanism of theta phase coding in the hippocampus.
    1. Cell Biology

    Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy

    Svasti Haricharan, Jie Dong ... Yi Li
    The transcription factor STAT5 mediates the increased breast cancer risk associated with a late age pregnancy, but intermittent anti-STAT5 treatment can lower this risk and thus prevent breast cancer.
    1. Neuroscience
    2. Physics of Living Systems

    Replay as wavefronts and theta sequences as bump oscillations in a grid cell attractor network

    Louis Kang, Michael R DeWeese
    An experimentally supported model of grid cells naturally enables them to participate in firing sequences that encode rapid trajectories in space.
    1. Neuroscience

    Synaptic learning rules for sequence learning

    Eric Torsten Reifenstein, Ikhwan Bin Khalid, Richard Kempter
    Through mathematical analysis and computer simulations, the neuronal underpinnings of feasible models of sequence learning are delineated.

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