Epigenomic and transcriptomic analysis reveals that paternal obesity influences sperm histone H3 lysine 4 tri-methylation enrichment and placenta gene expression, which in turn negatively impact its development and function in a manner that may contribute to metabolic disease in offspring.

Aneuploid human embryonic cells are eliminated by p53-mediated apoptosis in a gene dosage dependent manner.

Clonal naïve human embryonic stem cells assemble an Arp2/3 complex-dependent contractile actin filament ring around colonies that promotes tensional forces favoring cell-cell adhesion and nuclear translocation of YAP to maintain ground-state pluripotency.

The utility of an in vitro cell culture system for studies of molecular mechanisms underlying the initial induction and subsequent propagation of environmentally induced epimutations is demonstrated.