2,506 results found
    1. Chromosomes and Gene Expression

    Reporter-ChIP-nexus reveals strong contribution of the Drosophila initiator sequence to RNA polymerase pausing

    Wanqing Shao et al.
    Reporter-ChIP-nexus captures paused Pol II on transfected plasmids and shows that pausing stability is influenced by core promoter sequences, especially by the initiator with a G at +2 position.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic effects on promoter usage are highly context-specific and contribute to complex traits

    Kaur Alasoo et al.
    Re-analysis of large gene expression datasets with state-of-the-art quantification methods reveals additional candidate genes mediating complex trait associations.
    1. Neuroscience

    Uncertainty leads to persistent effects on reach representations in dorsal premotor cortex

    Brian M Dekleva et al.
    When Rhesus monkeys plan reaching movements of which they are not fully confident, a particular area of the brain represents both the chosen action as well as alternate movements, perhaps as an aid for error correction or learning.
    1. Chromosomes and Gene Expression

    Conserved noncoding transcription and core promoter regulatory code in early Drosophila development

    Philippe J Batut, Thomas R Gingeras
    Gene expression timing during Drosophila development is specified by multiple classes of RNA polymerase II core promoters, and the embryonic transcriptome includes thousands of evolutionarily conserved long noncoding RNAs.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Core promoter factor TAF9B regulates neuronal gene expression

    Francisco J Herrera et al.
    An orphan TBP-associated factor, TAF9B, works in conjunction with the histone acetyl-transferase PCAF as transcriptional co-regulators of neuronal differentiation.
    1. Neuroscience

    Contributions of local speech encoding and functional connectivity to audio-visual speech perception

    Bruno L Giordano et al.
    Seeing a speaker's face aids comprehension by facilitating functional connectivity between the temporal and frontal lobes.
    1. Neuroscience

    Causal manipulation of functional connectivity in a specific neural pathway during behaviour and at rest

    Vanessa M Johnen et al.
    Functional connectivity in the human brain reflects changes in synaptic plasticity induced with repeated paired stimulation.
    1. Neuroscience

    Motor Performance: Acetylcholine in action

    Erin M Wall, Sarah C Woolley
    The neurotransmitter acetylcholine influences how male finches perform courtship songs by acting on a region of the premotor cortex called HVC.
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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of a bacterial RNA polymerase holoenzyme open promoter complex

    Brian Bae et al.
    The crystal structure of bacterial RNA polymerase bound to the transcription bubble reveals key features that support the formation of a double-strand/single-strand DNA junction at the upstream edge of the −10 element where bubble formation initiates.

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