An orphan TBP-associated factor, TAF9B, works in conjunction with the histone acetyl-transferase PCAF as transcriptional co-regulators of neuronal differentiation.
Mirror neurons, including corticospinal neurons, in primary motor cortex of macaque monkeys, clearly dissociate between execution and observation of grasping actions while ventral premotor cortex (F5) maintains a similar representation.
When Rhesus monkeys plan reaching movements of which they are not fully confident, a particular area of the brain represents both the chosen action as well as alternate movements, perhaps as an aid for error correction or learning.
Reporter-ChIP-nexus captures paused Pol II on transfected plasmids and shows that pausing stability is influenced by core promoter sequences, especially by the initiator with a G at +2 position.
Gene expression timing during Drosophila development is specified by multiple classes of RNA polymerase II core promoters, and the embryonic transcriptome includes thousands of evolutionarily conserved long noncoding RNAs.
Neuroimaging provides novel insights into how the motor system represents sequences of actions by automatically separating their spatial and temporal features for flexible skill production.
Laser-ablating neurons of a single genetic class reveals that Dbx1-derived interneurons comprise core respiratory rhythmogenic and premotor circuits and provides quantitative cellular parameters that govern network functionality