Reporter-ChIP-nexus captures paused Pol II on transfected plasmids and shows that pausing stability is influenced by core promoter sequences, especially by the initiator with a G at +2 position.

Re-analysis of large gene expression datasets with state-of-the-art quantification methods reveals additional candidate genes mediating complex trait associations.

When Rhesus monkeys plan reaching movements of which they are not fully confident, a particular area of the brain represents both the chosen action as well as alternate movements, perhaps as an aid for error correction or learning.

Gene expression timing during Drosophila development is specified by multiple classes of RNA polymerase II core promoters, and the embryonic transcriptome includes thousands of evolutionarily conserved long noncoding RNAs.

An orphan TBP-associated factor, TAF9B, works in conjunction with the histone acetyl-transferase PCAF as transcriptional co-regulators of neuronal differentiation.

Seeing a speaker's face aids comprehension by facilitating functional connectivity between the temporal and frontal lobes.

Functional connectivity in the human brain reflects changes in synaptic plasticity induced with repeated paired stimulation.

Neuroimaging provides novel insights into how the motor system represents sequences of actions by automatically separating their spatial and temporal features for flexible skill production.

The crystal structure of bacterial RNA polymerase bound to the transcription bubble reveals key features that support the formation of a double-strand/single-strand DNA junction at the upstream edge of the −10 element where bubble formation initiates.

Integrative structural biology reveals a novel complex comprising the TATA-box-binding protein, TBP, and two subunits, TAF11 and TAF13, of General Transcription Factor TFIID, suggesting a new regulatory state in TFIID function in RNA polymerase II transcription initiation.