110 results found
    1. Cell Biology

    ACVR2A Facilitates Trophoblast Cell Invasion through TCF7/c-JUN Pathway in Pre-eclampsia Progression

    Shujing Yang, Huanyao Liu ... Fang He
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Developmental Biology

    Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling

    Maiko Kawasaki, Katsushige Kawasaki ... Atsushi Ohazama
    Cell-cell interaction between neural crest-derived cells and mesoderm-derived cells determine cell fate of mesoderm-derived cell in tongue development through Hh signaling.
    1. Neuroscience

    Sensitivity to vocal emotions emerges in newborns at 37 weeks gestational age

    Xinlin Hou, Peng Zhang ... Dandan Zhang
    Analysis of neonatal response reveals that at 37 weeks gestational age, infants exhibit a marked developmental shift in their ability to perceive emotional vocal prosody, highlighting a critical period for social emotional development with potential implications for early neurodevelopmental assessments.
    1. Developmental Biology
    2. Genetics and Genomics

    Early moderate prenatal alcohol exposure and maternal diet impact offspring DNA methylation across species

    Mitchell Bestry, Alexander N Larcombe ... David Martino
    Early moderate consumption of alcohol in pregnancy was sufficient to disrupt the fetal epigenome in newborn mice, and high folate maternal diets had a mitigating effect.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry

    Wei Q Deng, Nathan Cawte ... Sonia S Anand
    Epigenetic signature of maternal smoking contributes to smaller body size and lower birth weight in newborns of European and South Asian ancestry.
    1. Developmental Biology
    2. Medicine

    SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction

    Stephen E Flaherty III, Olivier Bezy ... Zhidan Wu
    Investigation of mouse models from forward mutagenetic screen reveals that the gene Spag7 is essential for embryonic development and energy homeostasis later in life.
    1. Developmental Biology

    Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis

    Siyuan Cheng, Ivan Fan Xia ... Stefania Nicoli
    Flow hemodynamic activation of endothelial klf2a is a mechanism regulating initial vascular smooth muscle cell differentiation on circle of Willis arteries.
    1. Neuroscience

    Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer’s disease

    Elissavet Chartampila, Karim S Elayouby ... Helen E Scharfman
    Supplementing the diet in early life with choline improved memory, neuronal morphology, and neuronal activity in mice with a genetic form of Alzheimer's disease, whereas low choline had mixed effects.
    1. Evolutionary Biology

    Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development

    Tian Yue, Yongbo Guo ... Bing Su
    Comparative transcriptome analyses of human placenta reveal regulatory divergence between native highlanders and lowland immigrants living at high altitude, and a sex-biased pattern of genetic adaptation.
    1. Developmental Biology

    Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts

    Yongfeng Luo, Ke Cao ... Wei Shi
    Disrupted mesenchymal Bmpr1a-mediated signaling in fetal mouse lung leads to abnormal airway development and congenital pulmonary cyst formation.

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