110 results found
    1. Neuroscience

    Memory for incidentally learned categories evolves in the post-learning interval

    Yafit Gabay, Avi Karni, Lori L Holt
    Incidental experiences can lead to lasting category knowledge, demonstrating that humans forage for information to acquire and consolidate new knowledge even when learning is not strictly necessary for success on an ongoing task.
    1. Neuroscience

    Learning accurate path integration in ring attractor models of the head direction system

    Pantelis Vafidis, David Owald ... Richard Kempter
    A theoretical model combines self-supervised predictive learning with structural inductive biases to reveal how quasi-continuous attractors that perform accurate angular path integration can be learned from experience during development in the Drosophila and potentially other animal models.
    1. Cell Biology

    Differential regulation of hair cell actin cytoskeleton mediated by SRF and MRTFB

    Ling-Yun Zhou, Chen-Xi Jin ... Hao Wu
    In hair cells, the development and maintenance of the F-actin-enriched stereocilia and cuticular plates are differentially regulated by transcription factors SRF and MRTFB, and SRF–CNN2 is required for modulating actin dynamics of the stereocilia and cuticular plate.
    1. Developmental Biology
    2. Neuroscience

    Dual midbrain and forebrain origins of thalamic inhibitory interneurons

    Polona Jager, Gerald Moore ... Alessio Delogu
    Thalamic interneurons in the mouse thalamus are often overlooked because of their extremely low numbers, however they are developmentally complex and related to those of larger-brained species.
    1. Chromosomes and Gene Expression

    Intergenerational epigenetic inheritance of cancer susceptibility in mammals

    Bluma J Lesch, Zuzana Tothova ... David C Page
    Genetic knockout of the histone demethylase Kdm6a in the mouse germ line leads to elevated cancer incidence in genetically wild type offspring.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cells

    Hourinaz Behesti, Arif Kocabas ... Mary E Hatten
    Human pluripotent stem cell modeling of the ATOH1 lineage identifies a temporal shift in the expression of key transcriptional regulators in the developing human cerebellum, this molecular divergence may drive the protracted development of the human cerebellum compared to rodents.
    1. Developmental Biology

    Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling

    Maiko Kawasaki, Katsushige Kawasaki ... Atsushi Ohazama
    Cell-cell interaction between neural crest-derived cells and mesoderm-derived cells determine cell fate of mesoderm-derived cell in tongue development through Hh signaling.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Identification of autosomal cis expression quantitative trait methylation (cis eQTMs) in children’s blood

    Carlos Ruiz-Arenas, Carles Hernandez-Ferrer ... Mariona Bustamante
    A catalogue of associations between DNA methylation and gene expression in children will improve the interpretation of Epigenome-Wide Association Studies.
    1. Neuroscience

    Infants are superior in implicit crossmodal learning and use other learning mechanisms than adults

    Sophie Rohlf, Boukje Habets ... Brigitte Röder
    Electrophysiological activity indicates superior implicit crossmodal learning in infants and a change in learning mode from infancy to adulthood.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genetic loci and metabolic states associated with murine epigenetic aging

    Khyobeni Mozhui, Ake T Lu ... Steve Horvath
    Age-dependent changes in DNA methylation are tightly coupled to the metabolic state, and is partly under genetic regulation, and longer lifespan is associated with lower epigenetic entropy at CpGs that increase in methylation with age.

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