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    1. Cell Biology

    Hsf1 and the molecular chaperone Hsp90 support a ‘rewiring stress response’ leading to an adaptive cell size increase in chronic stress

    Samarpan Maiti, Kaushik Bhattacharya ... Didier Picard
    Human cells adapt to chronic mild stresses, such as slightly elevated temperature, by getting larger in a process that couples increased translation to increased cell size in an Hsp90-dependent manner.
    1. Neuroscience

    Sex-dependent effects of in utero cannabinoid exposure on cortical function

    Anissa Bara, Antonia Manduca ... Olivier J Manzoni
    Adult male, but not female, rats showed altered neuronal function, inhibited synaptic plasticity and diminished social behavior following cannabinoid exposure during gestation in a model of cannabis use during pregnancy.
    1. Developmental Biology
    2. Genetics and Genomics

    Early moderate prenatal alcohol exposure and maternal diet impact offspring DNA methylation across species

    Mitchell Bestry, Alexander N Larcombe ... David Martino
    Early moderate consumption of alcohol in pregnancy was sufficient to disrupt the fetal epigenome in newborn mice, and high folate maternal diets had a mitigating effect.
    1. Neuroscience

    Selective increases in inter-individual variability in response to environmental enrichment in female mice

    Julia C Körholz, Sara Zocher ... Gerd Kempermann
    The classical experimental paradigm of "enriched environments" is repositioned as a tool to address the question of how behavioral activity and the environment contribute to specific differences between individuals.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    eIF2B activator prevents neurological defects caused by a chronic integrated stress response

    Yao Liang Wong, Lauren LeBon ... Carmela Sidrauski
    Boosting the function of translation factor eIF2B by chronic small molecule administration prevents pathology in a neurodegenerative model of Vanishing White Matter disease characterized by a maladaptive stress response.
    1. Neuroscience

    NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses

    Brandon W Hughes, Benjamin M Siemsen ... Makoto Taniguchi
    Social defeat stress induces transcription factor Npas4 expression in the medial prefrontal cortex and its chronic stress-induced changes in excitatory synaptic transmission, reduction of dendritic spine density, and anhedonia-like behaviors.
    1. Epidemiology and Global Health

    External validation of postnatal gestational age estimation using newborn metabolic profiles in Matlab, Bangladesh

    Malia SQ Murphy, Steven Hawken ... Kumanan Wilson
    Gestational age estimation models derived from newborn screening bloodspot samples are effective on data obtained from both heel prick and cord blood samples in low-resource settings.
    1. Developmental Biology
    2. Neuroscience

    Altered corticolimbic connectivity reveals sex-specific adolescent outcomes in a rat model of early life adversity

    Jennifer A Honeycutt, Camila Demaestri ... Heather C Brenhouse
    Early life adversity led to hyper-innervation from the basolateral amygdala to the prefrontal cortex earlier in females than males and disrupted maturation of functional connectivity, which predicted anxiety-like outcomes.
    1. Neuroscience

    Eco-HAB as a fully automated and ecologically relevant assessment of social impairments in mouse models of autism

    Alicja Puścian, Szymon Łęski ... Ewelina Knapska
    An innovative, fully computerized approach for measuring spontaneous social behavior in mice closely follows murine ethology, eliminates crucial sources of data irreproducibility and enables fast, inexpensive assessment of sociability in group-housed subjects.
    1. Epidemiology and Global Health

    Risk of psychiatric disorders among the surviving twins after a co-twin loss

    Huan Song, Henrik Larsson ... Unnur A Valdimarsdóttir
    A population-based analysis demonstrates that surviving twins who lose their co-twins by death are at considerably elevated risks of developing psychiatric disorders.