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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The C-terminal tail of the bacterial translocation ATPase SecA modulates its activity

    Mohammed Jamshad et al.
    The interaction of SecA with its substrate proteins is regulated by its evolutionarily conserved C-terminal tail, which autoinhibits SecA unless SecA binds to the ribosome.
    1. Developmental Biology
    2. Human Biology and Medicine

    Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion

    Holly Hardy et al.
    Chick optic fissure closure is a powerful new model system for epithelial fusion and has revealed Netrin-1 as a conserved and essential mediator of tissue fusion in multiple contexts.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons

    Disi An et al.
    Stem cell-derived motor neurons with differential ALS vulnerability identified proteasome activity as a possible mechanism that explains their differential sensitivity.
    1. Biochemistry and Chemical Biology

    A toolkit for studying cell surface shedding of diverse transmembrane receptors

    Amanda N Hayward et al.
    The modularity and unequivocal input/response of Notch signaling are harnessed to measure cell-surface shedding of diverse transmembrane receptors to identify new proteolytic switches and detect modulation of proteolysis by therapeutics.
  1. eLife Ambassadors: Looking for inclusive funding options for early-career researchers

    A number of organisations have adopted practices that open up funding opportunities to a more diverse set of researchers.
    1. Neuroscience

    Functional and anatomical specificity in a higher olfactory centre

    Shahar Frechter et al.
    The Drosophila lateral horn, a higher olfactory brain area, contains >165 genetically defined cell types with stereotyped odour responses across animals and improved odor categorisation compared with their inputs.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The COMA complex interacts with Cse4 and positions Sli15/Ipl1 at the budding yeast inner kinetochore

    Josef Fischböck-Halwachs et al.
    The chromosomal passenger complex interacts with the inner kinetochore COMA complex through the Ctf19 C-terminus in vitro which is shown to be important for mediating accurate chromosome segregation.
  2. Webinar Report: Mental health support for early-career researchers

    Learn about some of the initiatives that are working to help researchers improve their mental health.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity

    Tamara M Sirey et al.
    Mitochondrial energy metabolism is post-transcriptionally regulated through an interplay between long and short non-coding RNAs.
    1. Neuroscience

    The relationship between spatial configuration and functional connectivity of brain regions revisited

    Janine Diane Bijsterbosch et al.
    The estimation of functional connectivity network matrices from resting state fMRI is driven by a combination of spatial and temporal factors in the presence of spatially overlapping network structure.