Neurons are mapped for developmental features (lineage, hemilineage, temporal identity) and connectomic features (morphology, synapse localization and connectivity) to reveal correlations that can be tested experimentally.

Studies in mice and neurons reveal how modulation of the axonal transport of synaptic vesicles via huntingtin phosphorylation influences the number of vesicles accumulating at the synapse, subsequent glutamate release, and behavior in mice.

Specific memories can be stored through changes in the postsynaptic cholinergic receptor composition at Drosophila mushroom body synapses.

Proteomic and genetic analysis discovers a new cytoskeletal mechanism of presynaptic short-term plasticity common across neuronal cell types.

A Cre-dependent reporter mouse line is generated, validated, and used to map cell-type-specific proteome and phosphoproteome of corticostriatal projections across postnatal development.

Genetic and pharmacological tools are used to dissect the mechanisms by which the presynaptic actin cytoskeleton facilitates membrane internalization at synapses and, thereby, neurotransmission.

Mitochondrial calcium influx plays distinct roles in presynapse formation, function and stability in sensory hair cells.

Excitatory and inhibitory postsynaptic receptors are maintained at corresponded postsynaptic sites with the different dependency of presynaptic neurons in the mature mammalian brain.