Proteomic and genetic analysis discovers a new cytoskeletal mechanism of presynaptic short-term plasticity common across neuronal cell types.

Mitochondrial calcium influx plays distinct roles in presynapse formation, function and stability in sensory hair cells.

Neurons are mapped for developmental features (lineage, hemilineage, temporal identity) and connectomic features (morphology, synapse localization and connectivity) to reveal correlations that can be tested experimentally.

CB₁-receptor-mediated inhibitory long-term depression (LTD) relies on both protein synthesis and ubiquitination to elicit structural changes that underlie long-term reduction of GABA release.

Loss of Kirrel3 selectively reduces DG-GABA mossy fiber filopodia and causes CA3 neuron hyper-activity during brain development.

Leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) are precisely localized to synaptic appositions, but do not control the assembly and function of the presynaptic nerve terminal.

The small GTPase Arf6 plays a role in setting the size of the readily releasable pool of synaptic vesicles and in the definition of the recycling route for endocytosed vesicles.

The essential role of presynaptic NMDA receptors for granule cell GABAergic output elucidates the function of reciprocal spines in recurrent and possibly lateral inhibition of mitral cells during olfactory processsing.

Ca2+ influx through Cav1.4 channels is required for the structural, but not the molecular organization of the rod photoreceptor synapse.

Open source software enables neuroscientists to integrate single neuron or synaptic-resolution datasets from different imaging modalities to analyse morphology and connectivity at the scale of whole brains and connectomes.