324 results found
    1. Genetics and Genomics
    2. Neuroscience

    Characterizing the Spatial Distribution of Dendritic RNA at Single Molecule Resolution

    Jihoon Kim, Jean G Rosario ... Junhyong Kim
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Neural mechanisms underlying the temporal organization of naturalistic animal behavior

    Luca Mazzucato
    Naturalistic animal behavior exhibits a complex organization in the temporal domain, whose variability stems from hierarchical, contextual, and stochastic sources and can be naturally explained in terms of metastable attractor models.
    1. Neuroscience

    Experience-dependent shaping of hippocampal CA1 intracellular activity in novel and familiar environments

    Jeremy D Cohen, Mark Bolstad, Albert K Lee
    Comparison of the intracellular activity of hippocampal neurons in novel and familiar environments reveals experience-dependent changes in inputs underlying the formation of stable representations of space.
    1. Neuroscience

    Excitatory and inhibitory synapse reorganization immediately after critical sensory experience in a vocal learner

    Ziqiang Huang, Houda G Khaled ... Richard HR Hahnloser
    Sensory acquisition of a motor target is associated with rapid removal of excitatory synapses and with rapid insertion of inhibitory synapses in the main song control area of songbirds.
    1. Neuroscience

    A neuronal least-action principle for real-time learning in cortical circuits

    Walter Senn, Dominik Dold ... Mihai A Petrovici
    A principle from which the neuronal dynamics and synaptic plasticity in arbitrary network architectures can be inferred, so that output errors are online minimized while simultaneously processing sensory input streams.
    1. Neuroscience

    Interacting rhythms enhance sensitivity of target detection in a fronto-parietal computational model of visual attention

    Amélie Aussel, Ian C Fiebelkorn ... Benjamin Rafael Pittman-Polletta
    A biophysical cortical circuit model reveals how thalamic inputs mediate complex dynamics in the frontal eye fields and lateral intraparietal area, enabling rhythmic enhancements in visual sensitivity observed behaviorally.
    1. Neuroscience

    Sleep-dependent upscaled excitability, saturated neuroplasticity, and modulated cognition in the human brain

    Mohammad Ali Salehinejad, Elham Ghanavati ... Michael A Nitsche
    The sleep-deprived brain in humans undergoes upscaled intracortical excitability which diminishes induction of LTP-like plasticity via transcranial electrical stimulation while converting the LTD-like to LTP-like plasticity and these physiological changes couple with impaired learning, memory, and attention at behavioral level.
    1. Neuroscience

    Maturation of cortical input to dorsal raphe nucleus increases behavioral persistence in mice

    Nicolas Gutierrez-Castellanos, Dario Sarra ... Zachary F Mainen
    Anatomical tracing, in combination with a genetic ablation approach, identifies a critical maturation period for neocortex to dorsal raphe afferents pivotal for the development of behavioral persistence over adolescence in mice.
    1. Stem Cells and Regenerative Medicine

    A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids

    Henrik Renner, Martha Grabos ... Jan M Bruder
    Automated liquid handling, whole mount staining, and clearing allow unbiased 3D quantitation of cell markers in human neural organoids with diameters of up to 1 mm at the single-cell level.
    1. Neuroscience

    MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders

    Adam J Harrington, Aram Raissi ... Christopher W Cowan
    Mice that lack the autism- and schizophrenia-linked gene MEF2C in cortical neurons have an imbalance of excitatory and inhibitory synapses, and impaired social and cognitive abilities.

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