14 results found
    1. Neuroscience

    Release-dependent feedback inhibition by a presynaptically localized ligand-gated anion channel

    Seika Takayanagi-Kiya et al.
    An anion-selective ligand gated channel acts as a presynaptic auto-receptor to modulate vesicle release and neuronal excitation.
    1. Neuroscience

    Dopaminergic and opioidergic regulation during anticipation and consumption of social and nonsocial rewards

    Sebastian Korb et al.
    Administration of dopamine and opioid receptor antagonists resulted in reduced reward anticipation (effort and increased negative facial reactions), but only administration of opioid antagonists resulted in reduced liking (facial reactions).
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

    Benjamin W Okaty et al.
    Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
    1. Neuroscience

    RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain

    Brooks G Robinson et al.
    Midbrain dopamine neurons use sophisticated secretory machinery to establish specialized sites for action potential-evoked release of dopamine from their cell bodies and dendrites.
    1. Neuroscience

    A cellular and regulatory map of the cholinergic nervous system of C. elegans

    Laura Pereira et al.
    Analyzing a map of all cholinergic neurons in the nematode C. elegans shows how these neurons are embedded in the C. elegans connectome and reveals the regulatory factors controlling their development.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

    Mattia Volta et al.
    LRRK2 G2019S knock-in mice are a genetically faithful model that recapitulates the slow disease progression of familial PD, with initial alterations to behaviour and neurotransmission providing early pathophysiological targets for neuroprotective interventions.
    1. Neuroscience

    Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making

    Karima Chakroun et al.
    Dopamine attenuates exploration during decision-making via a reduction of neural tracking of uncertainty.
    1. Neuroscience

    Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour

    Judit García-González et al.
    Zebrafish studies are able to predict loci and biological pathways affecting human behaviour, paving the way to better understanding of the biological underpinnings of psychiatric disease.
    1. Neuroscience

    Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks

    Gertrudis Perea et al.
    Astrocytes decode temporal interneuron activity and transform inhibitory into excitatory signals that impact excitatory synaptic strength and neuronal circuit function.
    1. Neuroscience

    Repeated social defeat stress enhances glutamatergic synaptic plasticity in the VTA and cocaine place conditioning

    Claire E Stelly et al.
    Enhanced glutamatergic synaptic plasticity in mesolimbic dopaminergic neurons may contribute to repeatedly stressed rats becoming more vulnerable to addiction.

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