124 results found
    1. Neuroscience

    An essential role for MEF2C in the cortical response to loss of sleep in mice

    Theresa E Bjorness et al.
    The transcription factor, MEF2C, mediates a change in approximately one half of the expressed frontal cortical transcriptome controlling cellular metabolism and synaptic strength in response to acute loss of sleep.
    1. Developmental Biology
    2. Neuroscience

    Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity

    Shinichiro Oku et al.
    Inclusion of a neuroligin alternatively spliced insert that interacts with a neurexin glycan modification promote development of functional synaptic connections between neurons and may help alleviate consequences of NLGN mutations.
    1. Stem Cells and Regenerative Medicine

    Novel C1q receptor-mediated signaling controls neural stem cell behavior and neurorepair

    Francisca Benavente et al.
    Complement C1q directly drives the behavior of human neural stem cells via a classical receptor signaling mechanism modulating their capacity for functional integration in vivo.
    1. Neuroscience

    Disynaptic cerebrocerebellar pathways originating from multiple functionally distinct cortical areas

    Julia U Henschke, Janelle MP Pakan
    Anatomical projections from sensory, motor, and association cortex to the cerebellum are precisely mapped, including cortical-precerebellar connections and terminal organization, providing insight into how the cerebellum may utilize cortical information.
    1. Neuroscience

    Three-dimensional synaptic organization of the human hippocampal CA1 field

    Marta Montero-Crespo et al.
    Volume electron microscopy reveals the synaptic organization of the neuropil of the human hippocampal CA1 field.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

    Benjamin W Okaty et al.
    Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
    1. Cell Biology
    2. Neuroscience

    Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin

    Julie Bruyère et al.
    Reducing Akt-mediated huntingtin phosphorylation decreases APP accumulation at the synapse by reducing its anterograde axonal transport and ameliorates learning and memory in a mouse model of familial Alzheimer disease.
    1. Neuroscience

    Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation

    Mathieu Letellier et al.
    Orthogonal to traditional paradigms that manipulate neuroligin expression level, optogenetic stimulation of tyrosine phosphorylation highlights a role of the intracellular domain of endogenous neuroligin-1 in excitatory synaptic differentiation and potentiation.
    1. Neuroscience

    A muscle-epidermis-glia signaling axis sustains synaptic specificity during allometric growth in Caenorhabditis elegans

    Jiale Fan et al.
    The work uncovers a muscle-epidermis-glia signaling axis, modulated by protease mig-17 and the basement membrane, that regulates synaptic allometry during growth in Caenorhabditis elegans.
    1. Developmental Biology
    2. Neuroscience

    Cell type composition and circuit organization of clonally related excitatory neurons in the juvenile mouse neocortex

    Cathryn R Cadwell et al.
    Excitatory cortical neurons with a shared developmental lineage are transcriptomically diverse and preferentially connect to each other vertically, across cortical layers, but not laterally within the same layer.

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