511 results found
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN

    Junjie Xu et al.
    The crystal structure of a large C-terminal fragment of Munc13-1 provides a key framework to understand how Munc13-1 mediates neurotransmitter release and presynaptic plasticity.
    1. Cell Biology
    2. Neuroscience

    Active presynaptic ribosomes in the mammalian brain, and altered transmitter release after protein synthesis inhibition

    Matthew S Scarnati et al.
    Local presynaptic protein synthesis occurring at established nerve terminals in the mammalian brain provides a mechanism for rapidly controlling or restoring presynaptic proteins that affect neurotransmitter release and presynaptic efficiency.
    1. Neuroscience

    Coincident postsynaptic activity gates presynaptic dopamine release to induce plasticity in Drosophila mushroom bodies

    Kohei Ueno et al.
    Presynaptic dopamine release is restricted to postsynaptic targets that have been coincidently activated.
    1. Neuroscience

    Release-dependent feedback inhibition by a presynaptically localized ligand-gated anion channel

    Seika Takayanagi-Kiya et al.
    An anion-selective ligand gated channel acts as a presynaptic auto-receptor to modulate vesicle release and neuronal excitation.
    1. Neuroscience

    ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains

    Richard G Held et al.
    The presynaptic active zone protein ELKS provides synapse-specific control of the pool of readily releasable vesicles and release probability.
    1. Neuroscience

    MCTP is an ER-resident calcium sensor that stabilizes synaptic transmission and homeostatic plasticity

    Özgür Genç et al.
    MCTP is a novel presynaptic calcium sensor, resident within the endoplasmic reticulum, that is required for normal baseline neurotransmission, short-term synaptic plasticity and presynaptic homeostatic plasticity.
    1. Cell Biology
    2. Neuroscience

    Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle

    Yunsheng Cheng et al.
    Experiments in C. elegans reveal how synaptotagmin and Rab3, the 'yin and yang' of synapses, control whether transmitter vesicles remain docked at the presynaptic membrane or release their contents into the synapse.
    1. Neuroscience

    Nanoscale dynamics of synaptic vesicle trafficking and fusion at the presynaptic active zone

    Thirumalini Vaithianathan et al.
    A combination of tethered diffusion of release-ready synaptic vesicles and vesicle-vesicle fusion supports neurotransmitter release at the presynaptic active zone of sensory synapses.
    1. Neuroscience

    Glutamate is required for depression but not potentiation of long-term presynaptic function

    Zahid Padamsey et al.
    Electrophysiological and optical analysis of neurotransmitter release at central synapses reveals that glutamate signalling is not required for the long-term potentiation (LTP) of presynaptic function, and instead only promotes presynaptic long-term depression (LTD).
    1. Cell Biology
    2. Neuroscience

    Memory: Can fearlessness come in a tiny package?

    Bryan W Luikart
    A molecule called microRNA-153 helps to prevent rats associating new environments with fear.
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