452 results found
    1. Neuroscience

    MDN brain descending neurons coordinately activate backward and inhibit forward locomotion

    Arnaldo Carreira-Rosario et al.
    A brain descending interneuron can coordinate a switch between two antagonistic behaviors (forward and backward locomotions).
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structure of alpha-synuclein fibrils

    Ricardo Guerrero-Ferreira et al.
    The alpha-synuclein fibril structure reported here buries residues 50-57 at the interface between its two protofilaments, suggesting that familial Parkinson's disease associated mutations in these residues lead to a structure not compatible with the one presented here.
    1. Neuroscience

    Characterization of developmental and molecular factors underlying release heterogeneity at Drosophila synapses

    Yulia Akbergenova et al.
    Active zone release probability is correlated with calcium channel density and calcium influx at single release sites, with release strength increasing in an activity-dependent manner during synapse maturation.
    1. Neuroscience

    Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency

    Kalina T Haas et al.
    Neuroligin 1 is a critical adhesion molecule which organizes AMPA receptor nanodomains in close vicinity to pre-synaptic release sites, and whose genetic or chemical disruption severely impairs synaptic transmission properties.
    1. Neuroscience

    Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans

    Xi Chen et al.
    Plexin controls the spatial distribution of synapses by locally inhibiting Rap2 small GTPase activity along the axon, and a Rap2 effector, TNIK, which also plays a key role in inhibiting synapse number.
    1. Neuroscience

    State-dependent cell-type-specific membrane potential dynamics and unitary synaptic inputs in awake mice

    Aurélie Pala, Carl CH Petersen
    Membrane potential recordings in awake mice from two genetically defined classes of neocortical inhibitory neurons reveal their distinct patterns of activity and unitary excitatory synaptic inputs, which are differentially modulated by behavior and local network activity.
    1. Neuroscience

    Recurrent network model for learning goal-directed sequences through reverse replay

    Tatsuya Haga, Tomoki Fukai
    The combination of short-term and long-term plasticity enables hippocampus to learn goal-directed paths through replay in a reversed order.
    1. Neuroscience

    Neurexin directs partner-specific synaptic connectivity in C. elegans

    Alison Philbrook et al.
    Investigation of synapse development using a single neuron system illuminates how individual neurons specify connectivity with their postsynaptic partners and the central role of the synaptic organizer neurexin in this process.

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