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    1. Immunology and Inflammation
    2. Medicine

    Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death

    Jack Gisby, Candice L Clarke ... James E Peters
    Severe COVID-19 is characterised by a plasma proteomic biomarker signature, indicating innate immune activation, leucocyte–endothelial interactions, and epithelial injury.
    1. Neuroscience

    The modulation of savouring by prediction error and its effects on choice

    Kiyohito Iigaya, Giles W Story ... Peter Dayan
    The anticipation of rewards turns out to have its own hedonic value, on top of that of the reward itself; a wide range of behavioral and neurophysiological data suggest that this anticipation is boosted by prediction errors.
    1. Ecology
    2. Evolutionary Biology

    Evolution of thorax architecture in ant castes highlights trade-off between flight and ground behaviors

    Roberto A Keller, Christian Peeters, Patrícia Beldade
    Body shape and behavioural specializations found across the castes of ant species evolved together and reflect different abilities for ground behaviors.
    1. Neuroscience

    Point of View: Predictive regulation and human design

    Peter Sterling
    Why does the human regulatory system, which evolution tuned for small satisfactions, now constantly demand 'more'?
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity

    Jason Tien, Christian J Peters ... Huanghe Yang
    The identification of four acidic amino acids as potential calcium-binding residues in the TMEM16A calcium-activated chloride channel furthers the molecular understanding of this ion channel family.
    1. Neuroscience

    Surface color and predictability determine contextual modulation of V1 firing and gamma oscillations

    Alina Peter, Cem Uran ... Martin Vinck
    Colored surfaces induce strong gamma-synchronization yet sparse firing in V1 when receptive field inputs are predicted from the surrounding spatial context.
    1. Neuroscience

    Conditioning sharpens the spatial representation of rewarded stimuli in mouse primary visual cortex

    Pieter M Goltstein, Guido T Meijer, Cyriel MA Pennartz
    Stimulus-reward learning sharpens the local representation of the visual space while leaving the overall retinotopic map intact.
    1. Immunology and Inflammation
    2. Neuroscience

    Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

    Alessio Vittorio Colombo, Rebecca Katie Sadler ... Arthur Liesz
    Experiments in a mouse model for Alzheimer’s disease using germ-free and conventionally housed animals reveal that microbiota-derived short-chain fatty acids promote the deposition of cerebral Aβ plaques.
    1. Structural Biology and Molecular Biophysics

    LRMP inhibits cAMP potentiation of HCN4 channels by disrupting intramolecular signal transduction

    Colin H Peters, Rohit K Singh ... John R Bankston
    A combination of patch clamp electrophysiology and FRET determine critical interactions between HCN4 channels and the ER resident protein LRMP and suggest a possible mechanism for reduced cAMP sensitivity.
    1. Medicine

    Meta-Research: COVID-19 medical papers have fewer women first authors than expected

    Jens Peter Andersen, Mathias Wullum Nielsen ... Reshma Jagsi
    Lockdowns in the United States caused by the COVID-19 pandemic appear related to a decrease in the number of women publishing research papers, especially as first authors.