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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Dynamics and consequences of spliceosome E complex formation

    Joshua Donald Larson, Aaron A Hoskins
    Single molecule fluorescence analysis of spliceosome E complex formation reveals how tuning of U1 binding to the 5' SS facilitates efficient capture of the snRNP by pre-mRNAs.
    1. Cell Biology
    2. Developmental Biology

    Philosophy of Biology: The analysis of living systems can generate both knowledge and illusions

    Antony M Jose
    By thinking about experimental techniques in terms of six broad approaches – perturbation, visualization, substitution, characterization, reconstitution, and simulation – researchers may be able to generate more reliable inferences.
    1. Developmental Biology
    2. Neuroscience
    Pond snail illustration

    The Natural History of Model Organisms: The unlimited potential of the great pond snail, Lymnaea stagnalis

    István Fodor et al.
    The great pond snail is a multipurpose model organism and a contemporary choice for addressing a wide range of biological questions, problems and phenomena in the laboratory and the field.
    1. Microbiology and Infectious Disease

    HIV in Women: How HIV exploits T cells in the endometrium

    Marta Rodriguez-Garcia
    Immune cells in the endometrium are targeted by HIV and re-programmed to allow them to survive and spread the virus throughout the body.
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  1. Research Culture: Framework for advancing rigorous research

    Walter J Koroshetz et al.
    Establishing a community of 'rigor champions' and building a comprehensive educational platform to teach the principles of rigorous science will help to ensure that the outputs of scientific research remain reliable and robust.
    1. Evolutionary Biology
    Neighboring communities of bonobos hunt different prey species

    Social Learning: Does culture shape hunting behavior in bonobos?

    Andrew Whiten
    New evidence that neighboring communities of bonobos hunt different prey species, despite extensive overlaps in where they live and hunt, is difficult to explain without invoking cultural factors.
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  2. Point of view: Motivating participation in open science by examining researcher incentives

    Sarah E Ali-Khan et al.
    A survey of researchers at the Montreal Neurological Institute and Hospital provides insights into the challenges and opportunities involved in adopting an open science policy across an entire patient-oriented academic institution.