16 results found
    1. Cell Biology

    A liquid-like organelle at the root of motile ciliopathy

    Ryan L Huizar et al.
    DynAPs reveal that biological phase separation provides the organizing principle for the complex process of dynein motor assembly in cells with motile cilia.
    1. Cell Biology
    2. Developmental Biology

    ZMYND10 functions in a chaperone relay during axonemal dynein assembly

    Girish R Mali et al.
    Chaperoning defects in axonemal dynein subunits trigger proteostatic clearance of dynein motors opening up the possibility of trialling proteostasis modulators to treat the motile ciliopathy primary ciliary dyskinesia (PCD).
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Basalin is an evolutionarily unconstrained protein revealed via a conserved role in flagellum basal plate function

    Samuel Dean et al.
    Basalins are intrinsically disordered proteins with astonishingly high-sequence divergence that are essential for building the transition zone basal plate and for proper central pair nucleation.
    1. Cell Biology
    2. Developmental Biology

    HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development

    Marisa Connell et al.
    HMMR regulates spindle positioning in neural and other cell types downstream of PLK1 and subsequently affects cortical NuMA-Dynein localization.
    1. Structural Biology and Molecular Biophysics

    The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications

    Ahmad Abdelzaher Zaki Khalifa et al.
    A structure of the ciliary inner junction at 3.6 Å resolution permits atomic modeling of six inner junction proteins and their interactions with acetylated lysine 40 loops of alpha tubulins.
    1. Developmental Biology

    Chloride channels regulate differentiation and barrier functions of the mammalian airway

    Mu He et al.
    The chloride channel Ano1/Tmem16a plays an essential and non-redundant role in the developing airway by inhibiting mucus cell hyperplasia and promoting proper immune function of the airway mucosal barrier.
    1. Cell Biology
    2. Developmental Biology

    Flattop regulates basal body docking and positioning in mono- and multiciliated cells

    Moritz Gegg et al.
    In cell types that acquire planar cell polarity, the protein Flattop regulates basal body docking and positioning.
    1. Cell Biology
    2. Developmental Biology

    Coordinated genomic control of ciliogenesis and cell movement by RFX2

    Mei-I Chung et al.
    Systems-level analysis in vertebrate ciliated epithelial cells shows that the network of genes activated by the transcription factor Rfx2 controls the development, migration, insertion and function of these cells.
    1. Cell Biology

    TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella

    Hiroaki Ishikawa et al.
    Loss of one protein from the intraflagellar transport complex leads to a defect in import of a specific sub-set of proteins into the flagellum.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

    Thomas Scambler et al.
    Dysfunction and overexpression of ENaC-mediated sodium influx exacerbates activation of NLRP3-inflammasome mediated inflammation in cells with CF-associated mutations and is modulated by inhibition of these amiloride-sensitive sodium (Na+) channels.

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