278 results found
    1. Ecology

    A SLC4 family bicarbonate transporter is critical for intracellular pH regulation and biomineralization in sea urchin embryos

    Marian Y Hu, Jia-Jiun Yan ... Meike Stumpp
    Cellular carbon accumulation systems are a fundamental prerequisite for biomineralization to stabilize pH and to supply inorganic carbon for CaCO3 precipitation under changing environmental conditions.
    1. Developmental Biology

    Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse

    Céline Portal, Panteleimos Rompolas ... Carlo Iomini
    Primary cilia of neural crest-derived cells mediate Indian hedgehog-induced signal transduction in the periocular mesenchyme and are required for normal anterior segment development.
    1. Developmental Biology
    2. Evolutionary Biology

    Architecture and evolution of the cis-regulatory system of the echinoderm kirrelL gene

    Jian Ming Khor, Charles A Ettensohn
    The transcriptional control system of a sea urchin gene reveals the deep evolutionary conservation of a gene regulatory network underlying morphogenesis.
    1. Developmental Biology

    Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling

    Maiko Kawasaki, Katsushige Kawasaki ... Atsushi Ohazama
    Cell-cell interaction between neural crest-derived cells and mesoderm-derived cells determine cell fate of mesoderm-derived cell in tongue development through Hh signaling.
    1. Developmental Biology
    2. Evolutionary Biology

    New hypotheses of cell type diversity and novelty from orthology-driven comparative single cell and nuclei transcriptomics in echinoderms

    Anne Meyer, Carolyn Ku ... Veronica Hinman
    Understanding novel cell types and their evolutionary history is re-evaluated using single nuclei transcriptomic approaches and their inferred underlying gene regulatory networks.
    1. Developmental Biology

    KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis

    Tingwei Guo, Xia Han ... Yang Chai
    A comprehensive analysis of mutant animal model shows the important role of KDM6B and how it cooperates with TFDP1 to achieve its functional specificity in regulating Trp53 expression to control the fate of cranial neural crest cells during palatogenesis.
    1. Developmental Biology

    A mammalian Wnt5a–Ror2–Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis

    Kuan Zhang, Erica Yao ... Pao-Tien Chuang
    Regulation of cellular properties such as ligand secretion and migratory ability through changes in the cytoskeleton mediated by a Wnt5a–Ror2–Vangl2 axis is a major determinant of alveolar formation.
    1. Developmental Biology

    Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis

    Junjun Jing, Jifan Feng ... Yang Chai
    The molecular regulatory mechanisms that control the interaction between mesenchymal stem cells and transit amplifying cells to maintain tissue homeostasis.
    1. Stem Cells and Regenerative Medicine

    Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells

    Nathan Kumar, Jenna Richter ... Karl Willert
    An expandable cell population derived from human pluripotent stem cells exhibits properties of mesoderm and is restricted to differentiate into derivatives of intermediate mesoderm.
    1. Developmental Biology

    Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria

    Kuan Zhang, Erica Yao ... Pao-Tien Chuang
    Mitochondrial activity and distribution control alveolar formation by conferring distinct cellular properties.

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