2,281 results found
    1. Cell Biology

    Glucose restriction drives spatial reorganization of mevalonate metabolism

    Sean Rogers et al.
    Genetic and biochemical analyses, coupled with fluorescence imaging, reveal that spatial compartmentalization of HMG-CoA Reductases at yeast ER-lysosome contacts modulates mevalonate pathway flux during glucose restriction, enabling metabolic adaptation.
    1. Neuroscience

    Network dynamics underlying OFF responses in the auditory cortex

    Giulio Bondanelli et al.
    Computational modeling demonstrates that population dynamics of neural calcium activity following stimulus offset are consistent with a network mechanism based on recurrent interactions.
    1. Evolutionary Biology

    How oscillating aerodynamic forces explain the timbre of the hummingbird’s hum and other animals in flapping flight

    Ben J Hightower et al.
    A first-principles acoustics model reveals how the acoustic spectrum generated by flapping wings originates from oscillating aerodynamic forces, and is validated by in vivo aerodynamic force measurements and acoustic holography.
    1. Neuroscience

    Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner

    Kang-Ying Qian et al.
    Male pheromone environment increases the cholinergic synaptic transmission at the neuromuscular junction in Caenorhabditis elegans hermaphrodites during development, decreasing hermaphrodites' locomotion activity and promoting mating efficiency.
    1. Immunology and Inflammation
    2. Neuroscience

    Development and characterization of a chronic implant mouse model for vagus nerve stimulation

    Ibrahim T Mughrabi et al.
    Long-term, dose-controlled vagus nerve stimulation (VNS) is feasible in mice using a multi-lab validated implantation procedure, allowing therapeutic testing of VNS in many disease models.
    1. Neuroscience

    Slowing the body slows down time perception

    Rose De Kock et al.
    The perception of time is influenced by movement environments, with slower movements associated with shorter perceived time intervals.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation

    Emma Carley et al.
    Forces stemming from cell-matrix adhesions, but not cell-cell adhesions, are directly transmitted to the nuclear lamina to regulate epidermal cell fate.
    1. Neuroscience

    A visual pathway for skylight polarization processing in Drosophila

    Ben J Hardcastle et al.
    Circuit tracing and in vivo calcium imaging reveals neurons conveying polarized light information from photoreceptors to the central brain, transforming patterns in the sky into a directional cue for navigation.
    1. Computational and Systems Biology

    Mouse aging cell atlas analysis reveals global and cell type-specific aging signatures

    Martin Jinye Zhang et al.
    Comprehensive single-cell transcriptome analysis reveals global and tissue-specific aging markers and characterizes the heterogeneous aging status of different cell types and tissues in mouse.
    1. Cell Biology
    2. Neuroscience

    Neuronal junctophilins recruit specific CaV and RyR isoforms to ER-PM junctions and functionally alter CaV2.1 and CaV2.2

    Stefano Perni, Kurt Beam
    Neuronal junctophilins 3 and 4 similarly recruit and functionally modify P/Q and N-type calcium channels, but differentially recruit the three ryanodine receptor isoforms to endoplasmic reticulum-plasma membrane junctions.

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