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    1. Neuroscience

    Recurrent circuit dynamics underlie persistent activity in the macaque frontoparietal network

    Eric Hart, Alexander C Huk
    Simultaneous recordings of neural ensembles in both the frontal and parietal cortices reveal how persistent activity can be maintained in the primate brain during visuospatial working memory.
    1. Developmental Biology
    2. Neuroscience

    Lmx1b is required at multiple stages to build expansive serotonergic axon architectures

    Lauren J Donovan et al.
    A continuously expressed LIM HD factor, Lmx1b, acts at successive stages to orchestrate the progressive morphological maturation of a long-range profusely arborized neuromodulatory axonal projection pathway.
    1. Neuroscience

    Sparse activity of identified dentate granule cells during spatial exploration

    Maria Diamantaki et al.
    Morphologically-mature granule cells with complex dendritic trees contribute to a sparse representation of space in the rat dentate gyrus.
    1. Neuroscience

    Object vision to hand action in macaque parietal, premotor, and motor cortices

    Stefan Schaffelhofer, Hansjörg Scherberger
    The cortical grasping circuit separates but shares visual and motor processes to transform object attributes into appropriate hand movements.
    1. Neuroscience

    Mouse V1 population correlates of visual detection rely on heterogeneity within neuronal response patterns

    Jorrit S Montijn et al.
    Heterogeneity of neural responses in mouse cortex correlates better with visual detection than mean population activity.
    1. Neuroscience

    High-order thalamic inputs to primary somatosensory cortex are stronger and longer lasting than cortical inputs

    Wanying Zhang, Randy M Bruno
    Secondary thalamic nuclei may provide stronger, longer-lasting input to superficial layers of primary sensory cortex than other cortical areas can.
    1. Neuroscience

    Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice

    Li Fan et al.
    A general cytoplasmic signaling mechanism for the novel functions of diverse alpha protocadherins in cortical neuron migration and actin cytoskeletal dynamics as well as dendrite morphogenesis in the brain.
    1. Computational and Systems Biology
    2. Neuroscience

    Decoupling kinematics and mechanics reveals coding properties of trigeminal ganglion neurons in the rat vibrissal system

    Nicholas E Bush et al.
    Primary sensory neurons of the rat whisker system encode contact with objects in terms of the forces exerted on whiskers, rather than the induced whisker movements.
    1. Neuroscience

    Neural population dynamics in motor cortex are different for reach and grasp

    Aneesha K Suresh et al.
    The neuronal activity in primary motor cortex does not exhibit smooth low-dimensional dynamics during grasp as it does during reach.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

    Roman O Fedoryshchak et al.
    Interaction of cofactor Phactr1 with PP1 creates a composite substrate-binding surface that defines the sequence specificity of the Phactr1/PP1 holoenzyme.