5,897 results found
    1. Ecology

    Experimental and observational studies find contrasting responses of soil nutrients to climate change

    ZY Yuan et al.
    Experimental manipulations and environmental gradients, the two common-used approaches, are not at all comparable for predicting the impacts of climate change on nutrient cycling.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Functional proteomic atlas of HIV infection in primary human CD4+ T cells

    Adi Naamati et al.
    Identification and characterisation of proteins and processes regulated by HIV in primary human CD4+ T cells using an HIV reporter virus for one-step, antibody-free magnetic selection.
    1. Cell Biology

    A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

    Herschel S Dhekne et al.
    Pathogenic LRRK2kinase requires Rab10 and RILPL1 to block primary cilia formation, shortening cilia on cholinergic neurons needed for a hedgehog driven circuit that supports dopaminergic neurons in mouse brain.
    1. Neuroscience

    Developmental 'awakening' of primary motor cortex to the sensory consequences of movement

    James C Dooley, Mark S Blumberg
    Early in development, before neurons in primary motor cortex are involved in motor control, they undergo a rapid transition in how they process sensory information following sleep and wake movements.
    1. Human Biology and Medicine

    A homozygous FANCM mutation underlies a familial case of non-syndromic primary ovarian insufficiency

    Baptiste Fouquet et al.
    Bilallelic mutations of FANCM, a DNA-damage response gene whose heterozygous mutations predispose to breast cancer, are involved in a familial case of Primary Ovarian Insufficiency establishing a link between infertility and cancer.
    1. Neuroscience

    Associations between sounds and actions in early auditory cortex of nonhuman primates

    Ying Huang et al.
    Early auditory cortex of nonhuman primates represents associations between sounds and actions, in both spiking activity and local field potentials.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium

    Xiaowen Liu et al.
    The primary cilia polycystin proteins, polycystin-1 and polycystin-2, affect cilia length in the kidney collecting duct epithelia, but only polycystin-2 is required for the functional ion channel in this organelle.
    1. Neuroscience

    Targeted cortical reorganization using optogenetics in non-human primates

    Azadeh Yazdan-Shahmorad et al.
    Focal optogenetic stimulation strengthens functional connectivity between primary somatosensory and motor cortices in macaques, in a manner consistent with a Hebbian model of stimulus-driven plasticity.
    1. Computational and Systems Biology
    2. Neuroscience

    Dynamic range adaptation in primary motor cortical populations

    Robert G Rasmussen et al.
    Motor neurons adjust their sensitivity to direction of movement in a manner analogous to how neurons in the visual system adjust their sensitivity to light.
    1. Cell Biology

    The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium

    Weiping Wang et al.
    The anaphase promoting complex (APC) has an essential role in ubiquitin-mediated proteolysis in the disassembly of cilia.

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