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    1. Genetics and Genomics

    Transgenesis and web resources in quail

    Olivier Serralbo, David Salgado ... Christophe Marcelle
    Transfection of quail primordial germ cells considerably expands the possibilities of genome modifications in birds, elevating the quail to the rank of genetic laboratory animal models of reference.
    1. Genetics and Genomics

    Large, three-generation human families reveal post-zygotic mosaicism and variability in germline mutation accumulation

    Thomas A Sasani, Brent S Pedersen ... Aaron R Quinlan
    Rates of germline mutation accumulation are highly variable across families of similar genetic ancestry, and post-zygotic mosaicism is a substantial source of de novo mutations.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression

    Merrick D Pierson Smela, Christian C Kramme ... George M Church
    Making human stem cells express certain transcription factors can convert them into cells that are similar to ovarian granulosa cells, and perform several important functions of the ovary.
    1. Developmental Biology

    Antagonism between germ cell-less and Torso receptor regulates transcriptional quiescence underlying germline/soma distinction

    Megan M Colonnetta, Lauren R Lym ... Girish Deshpande
    A molecular duel between germline and somatic determinants ensures proper establishment of transcriptional quiescence in the primordial germ cells of early Drosophila embryos.
    1. Developmental Biology

    Dynamic filopodia are required for chemokine-dependent intracellular polarization during guided cell migration in vivo

    Dana Meyen, Katsiaryna Tarbashevich ... Erez Raz
    Functional analysis of filopodia by specific interference with their formation and distribution reveals a critical role in conferring intracellular polarity and in controlling the dynamic properties of chemokine-guided cell migration in vivo.
    1. Cell Biology
    2. Developmental Biology

    Correction: Independent regulation of mitochondrial DNA quantity and quality in Caenorhabditis elegans primordial germ cells

    Aaron ZA Schwartz, Nikita Tsyba ... Jeremy Nance
    1. Developmental Biology
    2. Genetics and Genomics

    In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse

    Marco Morselli, William A Pastor ... Matteo Pellegrini
    DNA methylation deposition is dependent on the presence of H3K4me3 and H3K36me3 histone marks.
    1. Developmental Biology

    Comprehensive profiling of migratory primordial germ cells reveals niche-specific differences in non-canonical Wnt and Nodal-Lefty signaling in anterior vs posterior migrants

    Rebecca G Jaszczak, Jay W Zussman ... Diana J Laird
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Developmental Biology

    Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

    Adriana K. Alexander, Karina F. Rodriguez ... Humphrey Hung-Chang Yao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology
    2. Evolutionary Biology

    Hedgehog signaling is required for endomesodermal patterning and germ cell development in the sea anemone Nematostella vectensis

    Cheng-Yi Chen, Sean A McKinney ... Matthew C Gibson
    The dependence of Nematostella germ cell specification on zygotic Hedgehog pathway activity supports the hypothesis that the eumetazoan common ancestor segregated its germline by inductive signals rather than maternal determinants.
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