The glypicans Dally-like protein and Dally reveal functional non-redundancy of the Hedgehog co-receptors Boi and Ihog through independent interactions and specifically regulate cytoneme dynamics via the Ihog FNIII domain, thus setting long-range signaling.
The shared capacity of stem cells to recapitulate initial body plan formation in vitro without species-specific cues, suggests the existence of alternative, evolutionarily conserved developmental trajectories.
Cell assemblies can use environmental cues created by their own respiration, such as oxygen gradients, to collectively guide themselves to more favorable locations in a remarkably robust and long-lasting way.
A mouse model where the splicing factor SRSF1 was prevented from accumulating in the cytoplasm revealed reduced translation of thousands of mRNAs and postnatal phenotypes particularly affecting multiciliated cells.
Selective transfer of mitochondria in the Balbiani body ensures high-quality oocyte mitochondria at extreme ploidy, explaining many enigmatic features of female germline architecture including germ cell loss.
A structure-based model of the chromosomal cohesin complex, accompanied by molecular-mechanistic simulations, explains cohesin's key role in topologically entrapping DNA, as well as its ability to alternatively extrude DNA loops.