6,253 results found
    1. Cell Biology
    2. Neuroscience

    Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses

    Kirby M Donnelly et al.
    Prion-like transfer of mutant huntingtin aggregates from presynaptic to postsynaptic neurons is enhanced by neuronal silencing and requires passage through the cytoplasm of Draper-expressing phagocytic glia in adult Drosophila brains.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules

    Sonja Kroschwald et al.
    A comparison in yeast and human cells reveals a remarkable variability in the properties of RNP granules and highlights a key role for protein disaggregation machines in regulating RNP granule assembly.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast

    James E Hughes Hallett et al.
    The key Target of Rapamycin Complex (TORC1) component Kog1 moves into bodies during glucose starvation to limit reactivation of the complex.
    1. Microbiology and Infectious Disease

    Prion propagation can occur in a prokaryote and requires the ClpB chaperone

    Andy H Yuan et al.
    The bacterium Escherichia coli possesses a permissive cytoplasmic environment and the requisite molecular machinery to support the propagation of prions.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Structural basis for the prion-like MAVS filaments in antiviral innate immunity

    Hui Xu et al.
    Mitochondrial anti-viral signaling proteins form three-stranded helical filaments in launching innate immune responses against RNA viruses.
    1. Developmental Biology

    Calcium handling precedes cardiac differentiation to initiate the first heartbeat

    Richard CV Tyser et al.
    High-resolution live imaging reveals how and when the mouse heart first starts to beat during development and how the onset of beating impacts on heart muscle cell maturation and heart formation.
    1. Genetics and Genomics

    Simultaneous quantification of mRNA and protein in single cells reveals post-transcriptional effects of genetic variation

    Christian Brion et al.
    A CRISPR-based dual reporter assay enables genetic mapping of DNA variants that specifically affect mRNA or protein levels in trans.
    1. Neuroscience

    The N-terminus of the prion protein is a toxic effector regulated by the C-terminus

    Bei Wu et al.
    A novel auto-inhibitory mechanism regulates the functional activity of the cellular prion protein, PrPC, providing for the first time a coherent molecular model for both its pathological and physiological effects.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A common bacterial metabolite elicits prion-based bypass of glucose repression

    David M Garcia et al.
    Activity-guided fractionation identifies the first bacterial metabolite that potently induces a prion in nature.
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon et al.
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.

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