2,400 results found
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon, Sarah E Lower ... Jing-Ke Weng
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
    1. Neuroscience

    An emerging view of neural geometry in motor cortex supports high-performance decoding

    Sean M Perkins, Elom A Amematsro ... Mark M Churchland
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Unraveling the developmental dynamic of visual exploration of social interactions in autism

    Nada Kojovic, Sezen Cekic ... Marie Schaer
    Children with ASD showed a significant divergence in gaze patterns compared to typically developing children, intensifying over early childhood, with implications for developmental and adaptive functioning.
    1. Computational and Systems Biology
    2. Developmental Biology

    Universality of clonal dynamics poses fundamental limits to identify stem cell self-renewal strategies

    Cristina Parigini, Philip Greulich
    Stem cell self-renewal strategies fall into two classes, and only strategies of different classes can be experimentally distinguished via static clonal data.
    1. Neuroscience

    A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments

    Gabriel Loewinger, Erjia Cui ... Francisco Pereira
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Physics of Living Systems

    Self-organization of kinetochore-fibers in human mitotic spindles

    William Conway, Robert Kiewisz ... Daniel J Needleman
    A biophysical model in which kinetochore microtubules nucleate at kinetochores and growth polward along nematic streamlines quantitatively explains kinetochore microtubule lengths, orientations, and spatially varying dynamics in metaphase human spindles.
    1. Cell Biology
    2. Plant Biology

    The Arabidopsis SAC9 enzyme is enriched in a cortical population of early endosomes and restricts PI(4,5)P2 at the plasma membrane

    Alexis Lebecq, Mehdi Doumane ... Marie-Cécile Caillaud
    SAC9 prevents the accumulation of PI(4,5)P2 in intracellular compartments, thereby contributing to clathrin-mediated endocytosis at the plasma membrane and regulating the cortical localization of its protein partner SH3P2.
    1. Neuroscience

    Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice

    Evan D Vickers, David A McCormick
    Procedures were developed to perform mesoscale 2-photon Ca2+ imaging simultaneously from all of mouse dorsolateral neocortex, facilitating identification of widespread neural ensembles with activity related to diverse aspects of behavior.
    1. Epidemiology and Global Health

    Efficacy profile of the CYD-TDV dengue vaccine revealed by Bayesian survival analysis of individual-level phase III data

    Daniel J Laydon, Ilaria Dorigatti ... Neil M Ferguson
    Bayesian survival analysis reveals comprehensive efficacy profile and mechanism of action for Sanofi-Pasteur’s CYD-TDV dengue vaccine, whereby vaccination acts as a silent, disease-free infection enhancing disease risk in seronegatives, but giving greater immunity in seropositives than two natural infections.
    1. Neuroscience

    Active information maintenance in working memory by a sensory cortex

    Xiaoxing Zhang, Wenjun Yan ... Chengyu T Li
    Delay-period activity of anterior piriform cortex is important for working memory tasks requiring active maintenance and encodes the maintained information.

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