Selective sweepstakes from pervasive positive selection, rather than demographic changes or random sweepstakes reproduction, is the primary determinant of reproductive skew and genetic diversity in the highly prolific Atlantic cod.
In causal inference, the premotor cortex dynamically integrates prior information and current sensory inputs to infer hidden structures, and selectively updates sensory representations in the parietal cortex to support behavior.
The analysis of injury-reactivated tectal radial glia in zebrafish reveals a stochastic cell-cycle entry and cell-state-dependent regulation of the balance between neurogenesis and gliogenesis.
María Rodríguez-López, Nicola Bordin ... Jürg Bähler
Large-scale screens and computational approaches reveal phenotypes for 3492 genes and gene-ontology predictions for 783 genes, including hitherto unstudied genes, which provides a potent platform to further dissect protein function.
Maksim Kleverov, Daria Zenkova ... Alexey A Sergushichev
Phantasus democratizes gene expression analysis, offering intuitive and interactive tools that streamline the exploration and analysis of user-provided data and over 96,000 public datasets.
Humans showed the most widespread asymmetric connectivity between the inferior parietal lobule subregions and the rest of the brain compared to macaques and chimpanzees, which shapes hemispheric specialization in primates.
Huyen Nguyen, Christian Wandell Thorball ... The Swiss HIV Cohort Study
The presence of certain HLA alleles drives the emergence or maintenance of otherwise deleterious drug-resistant mutations in patients living with HIV, even when the patient is antiretroviral treatment naïve.
New morphological data of a primitive placoderm fish demonstrate both high regionalization of squamation and the bipartite histological structure of scale are plesiomorphic for jawed vertebrates.
Electrophysiological and structural characterizations reveal that a previously proposed ion channel responsible for sensing mechanical pain is insensitive to poking or stretching stimuli for conducting ions and may serve as a coenzyme A-binding protein instead.
