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    1. Neuroscience

    Early life stress causes sex-specific changes in adult fronto-limbic connectivity that differentially drive learning

    Jordon D White, Tanzil M Arefin ... Arie Kaffman
    Mice exposed to complex early adversity show similar diffusion MRI changes to those reported in humans and sex-specific changes in connectivity that differentially affect contextual deficits in males and females.
    1. Computational and Systems Biology
    2. Neuroscience

    Front-end Weber-Fechner gain control enhances the fidelity of combinatorial odor coding

    Nirag Kadakia, Thierry Emonet
    In multi-channel sensory systems, gain adaptation can help maintain not only coding capacity across changes in signal intensity, but also combinatorial representations of odor identity.
    1. Neuroscience

    Uniting functional network topology and oscillations in the fronto-parietal single unit network of behaving primates

    Benjamin Dann, Jonathan A Michaels ... Hansjörg Scherberger
    Oscillatory synchronized hub neurons coordinate neural network activity across multiple brain areas.
    1. Physics of Living Systems

    Flower-like patterns in multi-species bacterial colonies

    Liyang Xiong, Yuansheng Cao ... Lev Tsimring
    Mechanical interactions between bacterial species with different motility characteristics play an important role in spatial-temporal dynamics of multi-species bacterial colonies and can lead to formation of complex patterns.
    1. Neuroscience

    Whole brain delivery of an instability-prone Mecp2 transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome

    Mirko Luoni, Serena Giannelli ... Vania Broccoli
    Global brain transduction of the instability-prone Mecp2 transgene by systemic AAV-PHP.eB administration is safe and effective in protecting male and female Mecp2 mutant mice from the Rett syndrome disease phenotype.
    1. Neuroscience

    Optimization of energy state transition trajectory supports the development of executive function during youth

    Zaixu Cui, Jennifer Stiso ... Theodore D Satterthwaite
    Structural network topology develops during adolescence to facilitate activation of the fronto-parietal executive system with lower theoretical energetic cost.
    1. Neuroscience

    Mapping brain-wide excitatory projectome of primate prefrontal cortex at submicron resolution and comparison with diffusion tractography

    Mingchao Yan, Wenwen Yu ... Zheng Wang
    A comprehensive excitatory projectome of the ventro-lateral prefrontal cortex in macaques was generated by using viral tracing integrated with serial two-photon tomography and diffusion tractography, thus providing new evidence of rejecting the monosynaptic connection of inferior fronto-occipital fasciculus in monkeys.
  1. Atomic design and pattern libraries: a robust front-end approach for eLife 2.0

    Paul Mollahan from digital consultancy Digirati discusses the innovative front-end approaches to eLife 2.0.
    1. Neuroscience

    Optogenetic strategies for high-efficiency all-optical interrogation using blue-light-sensitive opsins

    Angelo Forli, Matteo Pisoni ... Tommaso Fellin
    A new soma-targeted variant of the large-conductance blue-light-sensitive opsin CoChR combined with advanced optical stimulation methods allows high-efficiency all-optical neuronal imaging and stimulation in mouse brain in vivo.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Spatial modulation of individual behaviors enables an ordered structure of diverse phenotypes during bacterial group migration

    Yang Bai, Caiyun He ... Xiongfei Fu
    Bacterial population can coordinate individuals of different phenotypes by spatial modulation of their run-and-tumble behaviors, resulting in collective group migration with an ordered structure of phenotypes.