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    1. Computational and Systems Biology

    Generative modeling of multi-mapping reads with mHi-C advances analysis of Hi-C studies

    Ye Zheng et al.
    A statistical model rescues multi-mapping reads with high accuracy and demonstrates their impact in all facets of the analysis of genome-wide high throughput conformation capture datasets.
    1. Neuroscience

    Primate prefrontal neurons signal economic risk derived from the statistics of recent reward experience

    Fabian Grabenhorst et al.
    Neurons in prefrontal cortex track the variance of experienced rewards to guide economic decisions.
    1. Neuroscience

    Integrated externally and internally generated task predictions jointly guide cognitive control in prefrontal cortex

    Jiefeng Jiang et al.
    The dorsolateral prefrontal cortex integrates concurrent externally and internally generated predictions of task demand to guide information processing, while the medial prefrontal cortex corrects its prediction error based on actual task demand.
    1. Genetics and Genomics
    2. Neuroscience

    A genetic, genomic, and computational resource for exploring neural circuit function

    Fred P Davis et al.
    Transcriptomes of cells in the Drosophila visual system combined with anatomy and other information reveal new functional insight into the visual circuit.
    1. Computational and Systems Biology
    2. Neuroscience

    Uncovering the computational mechanisms underlying many-alternative choice

    Armin W Thomas et al.
    A comparison of different computational models reveals that looking behavior, during value-based choices from 9, 16, 25, or 36 snack foods, actively influences the subjective values of the available alternatives.
    1. Structural Biology and Molecular Biophysics

    Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

    Xue Fei et al.
    Cryo-EM structures of the ClpXP protease reveal how protein substrates are bound, show how spiral ClpX hexamers bind symmetry-mismatched heptameric ClpP rings, and suggest mechanisms for processive substrate translocation.
    1. Computational and Systems Biology

    Metabolic network percolation quantifies biosynthetic capabilities across the human oral microbiome

    David B Bernstein et al.
    A novel metabolic network analysis method enables large-scale computational predictions of biosynthetic capabilities across the human oral microbiome, revealing a unique cluster of fastidious microorganisms and potential metabolic interdependencies.
    1. Neuroscience

    Critical role for the mediodorsal thalamus in permitting rapid reward-guided updating in stochastic reward environments

    Subhojit Chakraborty et al.
    In monkeys, the integrity of the magnocellular subdivision of mediodorsal thalamus is important when using recent rewarded choices to promote persistence with a recently sampled choice during changing or uncertain reward guided-learning and decision-making tasks.
    1. Computational and Systems Biology

    Neural arbitration between social and individual learning systems

    Andreea Oliviana Diaconescu et al.
    Arbitration is formalised as the relative precision of predictions afforded by reward and social learning systems and is represented in modality-specific dopaminergic and dopaminoceptive regions, including the midbrain and amygdala.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states

    Sumin Jang et al.
    Mammalian germ layer differentiation is characterized by transitions through discrete cell states, which are transcriptionally as well as functionally distinct.