3,842 results found
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    High resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery

    Conor J Howard, Nathan S Abell ... Nathan B Lubock
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    High-Resolution Genome-Wide Maps Reveal Widespread Presence of Torsional Insulation

    Porter M Hall, Lauren A Mayse ... Michelle D Wang
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Neuroscience

    Visual homogeneity computations in the brain enable solving property-based visual tasks

    Georgin Jacob, RT Pramod, SP Arun
    Seemingly disparate property-based tasks (oddball search, same-different and symmetry) are solved by computing a novel image property, visual homogeneity, which is localized to the object selective cortex.
    1. Neuroscience

    An adaptable, reusable, and light implant for chronic Neuropixels probes

    Célian Bimbard, Flóra Takács ... Philip Coen
    The Apollo implant, an open-source device tested in eight laboratories, can be used to reversibly implant Neuropixels probes and track the activity of populations of neurons across days.
    1. Neuroscience

    A deep learning framework for automated and generalized synaptic event analysis

    Philipp S O’Neill, Martín Baccino-Calace ... Igor Delvendahl
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Neuroscience

    Dynamic Gamma Modulation of Hippocampal Place Cells Predominates Development of Theta Sequences

    Ning Wang, Yimeng Wang ... Dong Ming
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability

    Joshua D Garcia, Chenyu Wang ... Kevin J Bender
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Cell Biology
    2. Physics of Living Systems

    De novo identification of universal cell mechanics gene signatures

    Marta Urbanska, Yan Ge ... Jochen Guck
    A computational systems biology approach identifies a gene network module associated with single-cell mechanical phenotype changes across diverse mouse and human systems, with implications for on-demand engineering of cell stiffness.
    1. Biochemistry and Chemical Biology

    Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

    Gabriella O Estevam, Edmond Linossi ... James S Fraser
    A deep mutational scan of MET kinase domain variants reveals resistance and sensitizing mutations for 11 inhibitors, providing a mutation-specific reference for precision therapies and drug development.
    1. Neuroscience

    Novel and optimized mouse behavior enabled by fully autonomous HABITS: Home-cage Assisted Behavioral Innovation and Testing System

    Bowen Yu, Penghai Li ... Yaoyao Hao
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing

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