A hyperpolarization-activated cation channel, counteracting membrane depolarization, delimits the excitability of receptor neurons subjected to naturally prolonged stimulation to preserve the function of neighboring receptor neurons in Drosophila gustation.
Pablo J Delclos, Kiran Adhikari ... Richard Meisel
An integrative approach is used to identify a mechanism by which the fitness effects of Y chromosomes can manifest via trans effects on autosomal genes, through their effects on male courtship and other sexually selected traits.
A set of sexually dimorphic neurons in female flies is part of a recurrent neural network and drives minutes-long persistent neural activity and persistent social behaviors.
The metal-dependent protein phosphatase Nilkantha, a Drosophila PPM1A/B homolog, dephosphorylates Acinus thereby restraining starvation-independent autophagy.
Sudeshna Das Chakraborty, Hetan Chang ... Silke Sachse
Two-photon functional imaging linked to olfactory preference in Drosophila provides the first understanding of how odors are integrated, transformed, and represented in the lateral horn by an ensemble of higher-order glutamatergic lateral horn neurons.
Expression of Drosophila bitter receptors in taste neurons produced increased, decreased, or novel responses, supporting a model in which the response profile is determined by activation, inhibition, or competition among receptors.
Output neurons in the mushroom body of the fruit fly brain encode the positive or negative survival value of stimuli, enabling insects to choose adaptive approach and avoidance behaviors through associative learning.
Brian D DeAngelis, Jacob A Zavatone-Veth ... Damon A Clark
A simple, computationally efficient method provides spatiotemporally precise optogenetic perturbations in freely walking Drosophila, revealing the asymmetries and region-specificity of behavioral programs evoked by activating mechanosensory and chemosensory neurons.
