641 results found
    1. Stem Cells and Regenerative Medicine
    2. Human Biology and Medicine

    Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

    Marko Z Nikolić et al.
    Improved characterisation of human embryonic lung development highlights human-mouse differences and facilitates the development of defined culture conditions for the expansion of self-renewing, multipotent human lung epithelial progenitor cells.
    1. Developmental Biology

    Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors

    Lincoln T Shenje et al.
    Cardiac progenitors remain undifferentiated and expansive in the second pharyngeal arch that serves as a microenvironment, and Numb and Numblike are required for their renewal.
    1. Human Biology and Medicine

    Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors

    Vitor H Teixeira et al.
    Cell replenishment within the airways is governed by the random division of a population of basal progenitor cells, in a process that is accelerated in smokers.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development

    Wenwen Zhou et al.
    The conserved mechanism of Notch down-regulation by endo-lysosomal trafficking plays important roles in the proliferation and differentiation of stem and progenitor cells during embryogenesis or organogenesis in vertebrates.
    1. Cell Biology
    2. Developmental Biology

    Distribution of neurosensory progenitor pools during inner ear morphogenesis unveiled by cell lineage reconstruction

    Sylvia Dyballa et al.
    The first dynamic map of early neuronal and sensory progenitors in the whole otic vesicle reveals how progenitor domains remodel upon morphogenesis.
    1. Developmental Biology
    2. Neuroscience

    The Drosophila Sp8 transcription factor Buttonhead prevents premature differentiation of intermediate neural progenitors

    Yonggang Xie et al.
    The Drosophila equivalent of the human transcription factor Sp8 acts to ensure that neural progenitor cells undergo an appropriate number of cell divisions, thereby helping to regulate brain development and guard against tumor formation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice

    Kerstin Schmidt et al.
    The H3K4 methyltransferase Setd1b is intrinsically required for hematopoietic stem and progenitor cell homeostasis and regulates lineage specification in mice.
    1. Cell Biology
    2. Developmental Biology

    Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development

    Felipe Mora-Bermúdez et al.
    Neural progenitors in humans and chimpanzee organoids show remarkably similar cellular and molecular parameters, but metaphase is longer during human mitosis.
    1. Developmental Biology

    Position-dependent plasticity of distinct progenitor types in the primitive streak

    Filip J Wymeersch et al.
    Neuromesodermal and lateral/ventral mesoderm progenitors represent distinct committed states, governed by separate regulatory logics.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation

    Chee Wai Chua et al.
    Analyses of genetically engineered mouse models reveal the androgen receptor-independent properties of a luminal stem/progenitor cell in the prostate epithelium, and its ability to serve as a cell of origin for castration-resistant prostate cancer.

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