1,420 results found
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development

    Benoit Roch et al.
    A viable separation of function XRCC4 knock-in mutant mouse model recapitulates some aspects of XRCC4 deficiency in humans, notably the absence of immune deficiency.
    1. Cell Biology
    2. Neuroscience

    The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease

    Aurelie de Rus Jacquet et al.
    Extracellular vesicles are proposed as novel, non-cell-autonomous mediators of neuronal atrophy in Parkinson's disease.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Evolution of irreversible somatic differentiation

    Yuanxiao Gao et al.
    Irreversible differentiation into somatic cells is evolutionarily optimal if changing cell phenotype is costly, a few somatic cells already improve the organism's performance, and the organism is large enough.
    1. Ecology
    2. Evolutionary Biology

    Social-like responses are inducible in asocial Mexican cavefish despite the exhibition of strong repetitive behavior

    Motoko Iwashita, Masato Yoshizawa
    A new tracking method revealed the social-like interactions in the Mexican blind cavefish, which was thought to be evolutionarily lost, and also demonstrated its mammal-like antagonistic association between the social-like interaction and repetitive behavior.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    3′HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression

    Pamela Himadewi et al.
    The 3'HS1 CTCF binding site directly modulates chromosomal loops to regulate γ-globin expression through the accession of the hereditary persistence of fetal hemoglobin enhancer.
    1. Cancer Biology
    2. Cell Biology

    Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation

    Brian Spurlock et al.
    A mitochondria-based 'priming' of stemness happens by fine-tuned repression of the level or activity of the master regulator of mitochondrial fission, Drp1, which supports carcinogen-induced transformation in a keratinocyte model.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Variation in human herpesvirus 6B telomeric integration, excision, and transmission between tissues and individuals

    Michael L Wood et al.
    Human herpesvirus 6B can transition between telomere-integrated and free viral forms, and frequent telomere-loop-driven partial or complete viral genome excision events create mosaicism in germline carriers of inherited chromosomally integrated HHV-6B.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Information content differentiates enhancers from silencers in mouse photoreceptors

    Ryan Z Friedman et al.
    Silencers and enhancers targeted by a common transcription factor in photoreceptors are distinguished by the number and diversity of binding transcription factor binding sites they contain.
    1. Developmental Biology
    2. Neuroscience

    Unbiased identification of novel transcription factors in striatal compartmentation and striosome maturation

    Maria-Daniela Cirnaru et al.
    RNAseq and ATACseq are utilized to identify transcription factors participating in striatal compartmentation into striosome and matrix, and roles for Stat1, Olig2, and Foxf2 are validated in vitro and in vivo.

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