Joachim Linssen, Anthony Ermens ... Andre J van der Ven
Distinct haemocytometric parameters, including cell activation markers, combined in a prognostic score may support early identification of COVID-19 patients likely to deteriorate and thus may benefit from ICU admission.
Behavioral, pharmacological, optogenetic, electrophysiological and computational analyses suggest that the anterior dorsal striatum is a causal node in the network responsible for evidence accumulation.
Emanuela Abiusi, Paola Infante ... Francesco Danilo Tiziano
The identification of SMA-miR supports the pathogenic role of skeletal muscle in spinal muscular atrophy and, integrated in the SMA-score, may help to improve the phenotypic prediction for patients.
Haley Hieronymus, Rajmohan Murali ... Charles L Sawyers
The percentage of a tumor’s genome with alterations in copy number is correlated with increased mortality across a range of tumor types and can be measured using a clinically approved sequencing assay.
Patrick Grossmann, Olya Stringfield ... Hugo JWL Aerts
Radiomics allows automated quantification of the radiographic phenotype of a tumor across diverse patient cohorts and is connected to the underlying molecular pathway activities, which together determine the clinical outcome.
An unbiased transcriptomic analysis enhances understanding of inflammatory pathways and genes linked to TBM pathogenesis and mortality, identifying potential markers for poor prognosis or therapeutic targets.
Gayathri Nagaraj, Shaveta Vinayak ... Dimpy P Shah
Sociodemographic (age, race/ethnicity) and clinical (Eastern Cooperative Oncology Group performance status, pre-existing comorbidities, and active and progressing cancer) risk factors were associated with worse COVID-19 outcomes in patients with breast cancer.
Integrated molecular analysis demonstrated that colorectal cancer can be classified into four molecular subtypes (proliferative, immunomodulatory, immunosuppressed, and immune-excluded subtypes), providing valuable insight into the intricate relationship between tumor microenvironment heterogeneity and various clinical phenotypes.