720 results found
    1. Immunology and Inflammation

    Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells

    Yvette Robbins et al.
    Human NK cells engineered to express a PD-L1 chimeric antigen receptor can control murine and human tumors and reduce myeloid cells expressing high levels of PD-L1.
  1. Episode 67: June 2020

    In this episode, we hear about a controversial claim in plant science, why we cannot get enough of chocolate, HIV in women, sex as a biological variable, and why not all zebrafish like to mingle.
    1. Neuroscience

    Vestigial auriculomotor activity indicates the direction of auditory attention in humans

    Daniel J Strauss et al.
    Recordings of ear muscles in humans show that ears attempt to pivot in the direction that requires attention.
    1. Ecology
    2. Physics of Living Systems

    Ant collective cognition allows for efficient navigation through disordered environments

    Aviram Gelblum et al.
    When real ants confront the classical 'Ant-in-a-labyrinth' physics problem where a random walker traverses a percolated environment, they employ active extended sensing and collective cognition to outperform passive physical solutions.
  2. Annual Report: 2019 in review

    We reflect on eLife’s efforts to transform research communication through improvements to science publishing, technology and research culture.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

    Louise Menendez et al.
    Direct reprogramming of somatic cells to an inner ear sensory hair cell-like state provides an experimental platform to identify causes and treatments for hair cell loss and hearing deficits.
    1. Neuroscience

    Parvalbumin interneurons provide spillover to newborn and mature dentate granule cells

    Ryan J Vaden et al.
    Fast-spiking parvalbumin-expressing interneurons generate slow spillover-mediated GABAergic transmission to young adult-born and neighboring mature neurons of the dentate gyrus.
    1. Ecology

    Vessel noise levels drive behavioural responses of humpback whales with implications for whale-watching

    Kate R Sprogis et al.
    Controlled exposure experiments reveal that underwater vessel noise level from a motorised vessel is an adequate driver of behavioural disturbance in humpback whales.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

    Zoe A Stephenson et al.
    A novel toxicophore, a 1H-1,2,3-triazole, has been identified in a wide-number of therapeutically-relevant compounds, including two anti-cancer chemotherapeutics, which inhibits mitochondria function and is mechanistically linked to adverse cardiac-cell events.

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