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    1. Microbiology and Infectious Disease

    An improved bacterial single-cell RNA-seq reveals biofilm heterogeneity

    Xiaodan Yan, Hebin Liao ... Yingying Pu
    RiboD-PETRI, a cost-effective, equipment-free plate-based scRNA-seq technique that integrates a unique bacterial rRNA depletion protocol, significantly enhancing mRNA detection rate and revealing within-population heterogeneity, offering valuable insights for research applications.
    1. Computational and Systems Biology

    Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage

    Zhiwei Huang, Songhao Luo ... Jiajun Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis

    Amanda Mixon Blackwell, Yasaman Jami-Alahmadi ... Paul A Sigala
    Plasmodium parasites have repurposed the heme oxygenase scaffold from its canonical heme-degrading function to fulfill an essential and adaptive role in gene expression within the apicoplast organelle.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A conserved cell-pole determinant organizes proper polar flagellum formation

    Erick E Arroyo-Pérez, John C Hook ... Simon Ringgaard
    FipA is a novel component required for bacteria that rely on FlhF/FlhG to properly localize their flagella to the cell pole.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA assisted uptake and ribosomal protein RplL sensitivity

    Jingbo Kan, Adrian Morales ... Sean F Brady
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    Lacticaseibacillus rhamnosus P118 enhances host tolerance to Salmonella infection by promoting microbe-derived indole metabolites

    Baikui Wang, Xianqi Peng ... Min Yue
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Structure of human PIEZO1 and its slow inactivating channelopathy mutants

    Yuanyue Shan, Xinyi Guo ... Duanqing Pei
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Dynamics of antimicrobial resistance and virulence of Salmonella enterica serovar Dublin

    Cheryll M Sia, Rebecca L Ambrose ... Danielle J Ingle
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Biochemistry and Chemical Biology

    A synthetic method to assay polycystin channel biophysics

    Megan Larmore, Orhi Esarte Palomero ... Paul G DeCaen
    Synthetic polycystin proteins self-assemble as function channels when reconstituted in lipid vesicles.
    1. Cancer Biology

    Super-enhancer-driven ZFP36L1 promotes PD-L1 expression in infiltrative gastric cancer

    Xujin Wei, Jie Liu ... Huiqin Zhuo
    CUT-Tag is used to identify super-enhancers (SEs) for the first time in gastric cancer, and the mRNA decay mechanism activated by SE-driven ZFP36L1 in infiltrative gastric cancer along with innovative experimental evidence demonstrating SPI1/ZFP36L1/HDAC3/PD-L1 signaling axis are presented.
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