A combination of composite-likelihood and gene network-based methods to investigate the impact of Denisovan introgression on the evolution of complex (i.e., polygenic) adaptive traits in high-altitude populations of Tibetan/Sherpa ancestry.

Large extracellular vesicle extrusion that eliminates neuronal protein aggregates and organelles is potentiated by uterine filling, linking reproductive status to maternal nervous system health, and demonstrating mechanobiology components in exophergenesis.

The metabolite 2-hydroxybutyrate is an important aspect of exhaustion which leads to increased capacity in the branched chain amino acid degradation pathway.

A newly identified immunometabolic mechanism clarifies the aberrant trafficking of dendritic cells to lymph nodes in tuberculosis.

2-Oxoglutarate and Fe(II)-dependent dioxygenases from clade C23 are the major source of guanidine in plants and release guanidine from arginine or homoarginine by C5 or C6 hydroxylation, respectively.

Cysteine dioxygenase, a conserved and critical enzyme in sulfur amino acid metabolism, is activated by the hypoxia-inducible transcription factor.