683 results found
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species

    Man Zhu, Meng Ma ... Jing Yang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus

    Akanksha Bafna, Gareth Banks ... Patrick M Nolan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression

    Sir2 and Fun30 regulate ribosomal DNA replication timing via MCM helicase positioning and nucleosome occupancy

    Carmina Lichauco, Eric J Foss ... Antonio Bedalov
    Precocious ribosomal DNA replication in sir2 mutants requires Fun30.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Multiplexed Assays of Human Disease-relevant Mutations Reveal UTR Dinucleotide Composition as a Major Determinant of RNA Stability

    Jia-Ying Su, Yun-Lin Wang ... Chien-Ling Lin
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Surprising features of nuclear receptor interaction networks revealed by live-cell single-molecule imaging

    Liza Dahal, Thomas GW Graham ... Xavier Darzacq
    Type II nuclear receptors do not always compete for a limiting pool of their obligate partner RXRa.
    1. Developmental Biology
    2. Genetics and Genomics

    Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition

    Anne-Sophie Pepin, Patrycja A Jazwiec ... Sarah Kimmins
    Epigenomic and transcriptomic analysis reveals that paternal obesity influences sperm histone H3 lysine 4 tri-methylation enrichment and placenta gene expression, which in turn negatively impact its development and function in a manner that may contribute to metabolic disease in offspring.
    1. Neuroscience

    Progressive overfilling of readily releasable pool underlies short-term facilitation at recurrent excitatory synapses in layer 2/3 of the rat prefrontal cortex

    Jiwoo Shin, Seung Yeon Lee ... Suk-Ho Lee
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Spatial localization of hippocampal replay requires dopamine signaling

    Matthew R Kleinman, David J Foster
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification

    Louna Fruchard, Anamaria Babosan ... Zeynep Baharoglu
    tRNA Q34 modification impacts tyrosine codon decoding and leads to proteome reprogramming in response to antibiotic stress in Vibrio cholerae.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

    Ananda Kishore Mukherjee, Subhajit Dutta ... Shantanu Chowdhury
    Telomere-sensitive regulation of IL1R1 by the shelterin protein TERF2 modulates tumour macrophage inflitration in triple-negative breast cancer.
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