1,036 results found
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons

    Iris Jonkers et al.
    The elongation rate of RNA Polymerase II varies greatly between and along genes, as this enzyme accelerates from stable pausing to rapid elongation within genes, and is influenced by CG-content, exons and chromatin.
    1. Computational and Systems Biology

    CDK9-dependent RNA polymerase II pausing controls transcription initiation

    Saskia Gressel et al.
    CDK9 inhibition in human cells uncovers that Pol II pause duration regulates the frequency of productive transcription initiation.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency

    Maxim Greenberg et al.
    Three-dimensional chromatin architecture facilitates a promoter switch in order to ensure maintained expression of a gene involved in growth during embryonic stem cell differentiation.
    1. Chromosomes and Gene Expression

    The nucleosomal barrier to promoter escape by RNA polymerase II is overcome by the chromatin remodeler Chd1

    Peter J Skene et al.
    The ATP-dependent chromatin remodeler Chd1 controls nucleosome turnover to allow RNA Polymerase to transcribe in vivo.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Architecture and RNA binding of the human negative elongation factor

    Seychelle M Vos et al.
    The structural architecture of the 4-subunit, RNA-binding human negative elongation factor NELF is derived by a combination of X-ray crystallography and protein crosslinking.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism

    Huasong Lu et al.
    A new potent and selective CDK9 inhibitor induces the expression of the proto-oncogene MYC via a mechanism that depends on the bromodomain protein BRD4.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation

    Daniil Alpern et al.
    Physical and functional interactions between HNF4A and TAF4 coordinate HNF4A genomic occupancy with pre-initiation complex formation to activate post-natal hepatocyte gene expression.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    LynA regulates an inflammation-sensitive signaling checkpoint in macrophages

    Tanya S Freedman et al.
    Degradation of kinase LynA protects macrophages from activation unless cells sense a receptor-binding pathogen or inflammation
    1. Cell Biology
    2. Developmental Biology

    Alstrom syndrome gene is a stem-cell-specific regulator of centriole duplication in the Drosophila testis

    Cuie Chen, Yukiko M Yamashita
    Alms1a is a centrosomal protein that exhibits asymmetric localization between mother and daughter centrosomes in asymmetrically dividing stem cells in Drosophila testis, controlling centriole duplication.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Stem cell niche exit in C. elegans via orientation and segregation of daughter cells by a cryptic cell outside the niche

    Kacy L Gordon et al.
    A previously undetected dynamic cell structure orients the mitotic spindle of germ stem cells and grows over one daughter cell, thus helping to balance niche retention with niche exit.

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