620 results found
    1. Neuroscience

    The activity-dependent histone variant H2BE modulates the life span of olfactory neurons

    Stephen W Santoro, Catherine Dulac
    A genome-organizing protein that is present only in the olfactory system of mice has been found to orchestrate changes in the relative numbers of different odor-sensing neurons on the basis of how active these neurons are.
    1. Neuroscience

    Hierarchical organization of context in the hippocampal episodic code

    Susumu Takahashi
    Neurons in the hippocampus modulate the rates at which they fire, and the locations in which they fire, so as to encode the information that is central to forming memories about personal experiences.
    1. Genetics and Genomics

    Integrative genomic analysis of the human immune response to influenza vaccination

    Luis M Franco, Kristine L Bucasas ... Chad A Shaw
    By comparing gene expression in people before and after they received the influenza vaccine, researchers were able to identify genes that contribute to differences in individual responses to vaccination.
    1. Neuroscience
    2. Medicine

    Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury

    Shawniqua T Williams, Mary M Conte ... Nicholas D Schiff
    The therapeutic effects of the sleeping pill zolpidem in patients with disorders of consciousness may be due to recruitment of brain cells idling in abnormally low-frequency brain waves.
    1. Neuroscience

    Inferring eye position from populations of lateral intraparietal neurons

    Arnulf BA Graf, Richard A Andersen
    An area of visual-motor cortex called the lateral intraparietal area encodes eye position signals that support visually-guided behaviors and image stabilization.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    MicroRNAs shape circadian hepatic gene expression on a transcriptome-wide scale

    Ngoc-Hien Du, Alaaddin Bulak Arpat ... David Gatfield
    In the liver, microRNAs exert widespread functions in the modulation of phases and amplitudes of clock-controlled gene expression, but their influence on the core clock is remarkably mild.
    1. Stem Cells and Regenerative Medicine

    Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain

    John K Mich, Robert AJ Signer ... Sean J Morrison
    Flow cytometric isolation and fate mapping shows that neurosphere-initiating cells are highly mitotically active and persist only transiently in vivo, and are distinct from quiescent, long-lived neural stem cells.
    1. Developmental Biology

    The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways

    Qingqing Zhu, Lu Song ... Naihe Jing
    The transcription factor Pou3f1 triggers embryonic stem cells to become neuronal progenitor cells in two ways: by activating the expression of pro-neuronal genes and by blocking external inhibitory signaling cascades.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome

    Alessandro Costa, Ludovic Renault ... James M Berger
    The Mcm2-7 motor unwinds DNA using an approach distinct from that of superfamily III helicases, and accesses multiple ring configurations and assembly states during the initiation of DNA replication.
    1. Stem Cells and Regenerative Medicine

    Identification of a new stem cell population that generates Drosophila flight muscles

    Rajesh D Gunage, Heinrich Reichert, K VijayRaghavan
    Large flight muscle of Drosophila are made by the regulated amplification of a newly identified stem cell population.

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