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    1. Immunology and Inflammation
    2. Medicine

    The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline

    Danielle Janosevic et al.
    Single-cell RNA-sequencing identifies the precise cellular and molecular events that occur along the sepsis timeline in the kidney, pointing to potential biomarkers and therapeutic targets.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Defining human mesenchymal and epithelial heterogeneity in response to oral inflammatory disease

    Ana J Caetano et al.
    Single cell transcriptomic analysis provides a reference map for human oral muscosa in health and disease and a framework for the development of new therapeutic strategies.
    1. Evolutionary Biology
    2. Medicine

    Developing a theoretical evolutionary framework to solve the mystery of parturition initiation

    Antonis Rokas et al.
    This review considers the evolutionary processes and physiological mechanisms that maintain or end pregnancy in mammals to formulate general, testable theoretical models that provide insights into the biology of parturition.
    1. Cancer Biology

    Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy

    Richard Lee Barrett, Ellen Puré
    Long under-appreciated, fibroblast biology is a key aspect of understanding how the immune system responds to tumors and may hold the key to improving immunotherapy in this tricky space.
    1. Genetics and Genomics
    2. Medicine

    KDM5A mutations identified in autism spectrum disorder using forward genetics

    Lauretta El Hayek et al.
    Successful autism spectrum disorder gene discovery using forward genetics identifies KDM5A, which encodes a histone H3 lysine 4 demethylase, as a disease gene.
    1. Chromosomes and Gene Expression

    Sustained TNF-α stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness

    Zuodong Zhao et al.
    Sustained TNF-α induction consolidates transcriptional memory for faster, stronger, and more sensitive subsequent induction in an active DNA demethylation-dependent manner for memory genes including CALCB, a therapeutic target for migraine.
    1. Cancer Biology

    Protein phase separation and its role in tumorigenesis

    Shan Jiang et al.
    The current understanding of phase separation is summarized and its emerging roles in cancer are discussed in detail.
    1. Microbiology and Infectious Disease

    Lipid hijacking: A unifying theme in vector-borne diseases

    Anya J O'Neal et al.
    A conceptual and unifying framework with a critical appraisal of lipid hijacking by microbes cycling between an arthropod vector and a mammalian host is explored.
    1. Developmental Biology

    Pregnancy success in mice requires appropriate cannabinoid receptor signaling for primary decidua formation

    Yingju Li et al.
    Cannabinoid signaling is critical for integration of vascular system and uterine decidualization.
    1. Neuroscience

    Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination

    Sven Dannhäuser et al.
    An interdisciplinary approach uncovers a new antinociceptive molecular mechanism and shows that the adhesion GPCR CIRL adjusts the sensation of gentle touch and noxious mechanical insult in opposite directions.