72 results found
    1. Cancer Biology
    2. Computational and Systems Biology

    Identifying prostate cancer and its clinical risk in asymptomatic men using machine learning of high dimensional peripheral blood flow cytometric natural killer cell subset phenotyping data

    Simon P Hood et al.
    Diagnosing the presence and clinical significance of prostate cancer can be achieved using AI-based analysis of peripheral blood natural killer (NK) cell subset profiles.
    1. Cancer Biology

    KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D

    Sawan Kumar Jha et al.
    Both VEGF-C and VEGF-D can be activated by KLK3/PSA and Cathepsin D, producing two novel VEGF-C forms and the known VEGFR-2-specific form of VEGF-D.
    1. Computational and Systems Biology

    In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta

    Maria Pernemalm et al.
    Comprehensive mass spectrometry analysis of human plasma proteome reveals tissue leakage proteins, describes variability between individual plasma proteomes and demonstrates protein transfer across the placenta during pregnancy.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

    Natalie A Counihan et al.
    Plasmodium parasites secrete RhopH2 from the rhoptry organelle into their host red blood cell to facilitate the uptake of essential nutrients required for parasite replication and survival.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Epitope resurfacing on dengue virus-like particle vaccine preparation to induce broad neutralizing antibody

    Wen-Fan Shen et al.
    Despite size heterogeneity, an epitope-resurfaced mature-form dengue VLP has the potential to induce quaternary structure-recognizing broad cross-reactive neutralizing antibodies.
    1. Developmental Biology

    Oviductal estrogen receptor α signaling prevents protease-mediated embryo death

    Wipawee Winuthayanon et al.
    Cyclic estrogen signaling in oviduct epithelial cells suppresses oviduct luminal protease activity to allow survival and development of preimplantation embryos
    1. Cancer Biology
    2. Cell Biology

    Secretion of protein disulphide isomerase AGR2 confers tumorigenic properties

    Delphine Fessart et al.
    Epithelial tumors secrete the ER-resident AGR2 in the extracellular matrix to function as a novel essential microenvironmental regulator of epithelial tissue architecture, which leads to tumorigenicity.
    1. Cell Biology

    Greatwall promotes cell transformation by hyperactivating AKT in human malignancies

    Jorge Vera et al.
    Greatwall is a new oncogene that induces AKT hyperphosphorylation by promoting the degradation of the phosphatase PHLPP.
    1. Cell Biology
    2. Cancer Biology

    A role for PVRL4-driven cell–cell interactions in tumorigenesis

    Natalya N Pavlova et al.
    A protein called PVRL4 has a central role in a number of cancers that originate in epithelial tissue, and anti-PVRL4 antibodies could be used to treat some of these cancers.
    1. Microbiology and Infectious Disease

    Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

    Wannaporn Ittiprasert et al.
    Gene knock-out of the omega-1 ribonuclease of Schistosoma mansoni eggs resulted in immunologically impaired phenotype, showcasing the novel application of CRISPR/Cas9 genome editing and utility for functional genomics in schistosomes.

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